Autoimmunity and Homeostasis

[percyval577]

The current version of wikipedia on autoimmunity (august 2019) makes this interesting statement:

While a high level of autoimmunity is unhealthy, a low level of autoimmunity may actually be beneficial. Taking the experience of a beneficial factor in autoimmunity further, one might hypothesize with intent to prove that autoimmunity is always a self-defense mechanism of the mammal system to survive. The system does not randomly lose the ability to distinguish between self and non-self, the attack on cells may be the consequence of cycling metabolic processes necessary to keep the blood chemistry in homeostasis.

I find this hypothesis very reasonable. The article doesn´t give any literature for the hypothesis, so the hypothesis might not have already been focused on in a separate paper. This thread is thought to (occasionally) pursue this direction, as well as the other one arounf (as far as it doesn´t loose track to the hypothesis too much), so:

• autoantibodies as normal regulators
• autoantibodies as being regulated