Astrocytes' role in memories

Wishful

Senior Member
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Alberta
https://newatlas.com/biology/brain-stars-memories/

The study shows that astrocytes are integral to forming and accessing at least certain types of memories. I think it's likely that astrocytes are involved in ME symptoms, so ME might cause memory problems that way.

I don't recall seeing many comments about memory problems in this forum. Are my astrocytes failing to access those memories? Are PWME forgetting to post about memory problems? ;)
 

Dysfunkion

Senior Member
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617
I have memory loss in certain ways, one is consistent and one is more fluctuating. The flucating one depends on how well I feel that day brain inflammation wise and will make how my brain writes what happened during the day to memory or immediate short term memory better or worse. The other seems to do with how my brain simply records details in general. I will remember general experiences and representations of their content but what the actual content was I won't be able to remember unless I see it again and then I will remember it as I'm being shown. I also won't be able to remember names well unless I see them over and over again constantly daily. It makes talking about music and things I watched very difficult even if I enjoyed something and know what it was in representation from the memory imprint and the conditions around it.

So it's like in nutshell I'll remember representational states and information based on their content I can access through sensory memory but the labels of said content and the fine details can't immediately be recalled unless I'm shown them again. This may be behind why I experience music and other media so uniquely in ways people can't seem to understand. Even though the content can't be recalled entirely the sensory experiences of them can and I get the most value out of how media "feels" almost as if my brain takes an entirely different route in processing all incoming information.
 

Springbok1988

Senior Member
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183
I deal with a lot of memory issues. My short term and episodic memory are pretty bad. I have trouble recalling the days events, what happened yesterday, the day before, etc. I struggle to learn new things. I forget about birthdays and holidays. I forget things about my past. I forget about my own likes and dislikes.
It used to be worse and I’d forget my husband’s name or my dog’s name. I’d forget that some extended family members exist or couldn’t recall their names. That has thankfully improved.
 

Wishful

Senior Member
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6,458
Location
Alberta
I'm wondering whether I need to start keeping checklists, but I don't know whether that's ME or simply age.

It would be interesting if there was a correlation between memory problems and immune activation or some other astrocyte-affecting factor.
 

datadragon

Senior Member
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457
Location
USA
It would be interesting if there was a correlation between memory problems and immune activation or some other astrocyte-affecting factor.
There are different forms of memory problems. For example in alzheimers, regulating copper in the brain stops memory loss in a mouse model of Alzheimer's and usable copper is lowered from inflammation/immune activation. Alzheimer's disease is characterized by the presence of amyloid plaques in the patient's brain. These plaques sequester copper, and contain approximately five times as much as a healthy brain. A new molecule extracts the copper trapped in amyloid plaques, and reintroduces it in the brain's normal enzymatic circuit (which needs copper to function). Administered orally to an Alzheimer's mouse model, this molecule inhibits the memory loss among sick mice. https://medicalxpress.com/news/2020-12-copper-brain-memory-loss-mouse.html
 
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