Anyone tried "IgG Guard" Immunoglobulins by Dr. Rajsree? Opinions needed

[LongCovidOli]

Dear all
I suffer from ME/CFS from the second Moderna dose since June 2021. Brainfog, Fatigue, PEM, POTS, a burning feeling in the heart when doing too much. I'm housebound since summer 2022.

Has anyone tried this supplement? https://dr-rajsrees-public-supplement-store.myshopify.com/collections/frontpage/products/igg-guard
What do you guys think? Is it safe? Any risks involved?

I would love to hear some opinions.
Thanks a lot, Oliver

(I guess it has nothing to do with this here, right? https://pubmed.ncbi.nlm.nih.gov/38910072/)

 

[Dysfunkion]

Would also like to know, that is expensive at 30 doses per 4 pills too. Reviews look good but I'm always skeptical when I see a product on a small site I never heard of selling a very expensive product, with only glowing reviews claiming wild improvements with no negative side effects.

 

[katabasis]

I've tried oral immunoglobulin supplements before - there are actually quite a few cheaper brands that you could find on Amazon, as well as of related supplements like colostrum which contain immunoglobulins. In my experience they do have a small but significant impact on gut symptoms, but I found that over time these benefits decrease, and I no longer take the supplement.

It's important to distinguish oral immunoglobulins from dosage forms like IV or SC which get the immunoglobulins into systemic circulation. Immunoglobulins are basically big-ass proteins, too big to be absorbed through the gut without being broken down (at which point they become amino acids and lose their functionality as immunoglobulins). So any proximal effect of oral immunoglobulins is constrained to the gut itself. It's thought that they bind to pathogens and inflammatory substances in the gut, which can be helpful for IBS-spectrum symptoms, and may even have systemic effects by altering gut flora. But I think it's unlikely that they will really significantly treat ME/CFS the way IVIG (for instance) seems to in some cases.

For what it's worth, I also have been getting IVIG therapy for a few years now, and while it's been very helpful for my small fiber neuropathy symptoms (particularly the nerve pain), it has done very little for my fatigue, flu-like pain, brain fog, etc. that are more characteristic of ME/CFS.

 

[cfs since 1998]

For what it's worth, I also have been getting IVIG therapy for a few years now, and while it's been very helpful for my small fiber neuropathy symptoms (particularly the nerve pain), it has done very little for my fatigue, flu-like pain, brain fog, etc. that are more characteristic of ME/CFS.

Did it help with numbness? What about autonomic dysfunction (e.g. POTS or orthostatic hypotension)? I have suspected SFN but pain isn't really the major issue.

 

[katabasis]

Did it help with numbness? What about autonomic dysfunction (e.g. POTS or orthostatic hypotension)? I have suspected SFN but pain isn't really the major issue.

I didn't really have any numbness to begin with, so I can't speak to that. It did help some aspects of autonomic dysfunction though. Some of my symptoms typical of POTS (orthostatic hypotension, heart palpitations, shortness of breath, lightheadedness) are significantly better, but not cured completely. And disappointingly, the autonomic problems didn't seem to be the underlying cause of the main ME/CFS symptoms as some have speculated.

Of course there is so much variability in these diseases that it's hard to predict whether a given treatment will help an individual. I'd say IVIG is most likely to benefit when autoimmunity is involved (there are other causes of SFN - sarcoidosis, Sjogren's disease, diabetes, etc. where IVIG is probably less likely to help). Then again, you may not have SFN but instead some other autoimmune problem that ends up causing autonomic dysfunction. Some research suggests that a lot of people with ME/CFS have autoantibodies for beta-adrenergic and muscarinic receptors. This could absolutely cause autonomic problems but it's a pretty different etiology from what is generally considered SFN. I'm not aware of any research on how this kind of issue would be affected by IVIG, but IVIG does have efficacy in a wide range of autoimmune conditions, so it wouldn't surprise me if it helped here as well.