Kenny Banya
Senior Member
- Messages
- 356
- Location
- Australia
Specifically for fatigue
Welcome to Phoenix Rising!
Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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Viagra: I don't have enough money to buy stock in anything, but buying Pfizer a few months ago would have been almost as good as buying Microsoft in 1985. This drug works by inhibiting type 5 phosphodiesterase, one of the six known enzymes to degrade cyclic GMP (as important as cyclic AMP, but maybe not covered in biology class). Type 5 is supposed to be specific for the corpus cavemosurn of the penis and probably the clitoris as well. It is not all that specific, though, at least in my patients, who frequently experience flushing and headache. When Viagra works in CFS/FMS, patients experience a reduction in all symptoms. One patient whom I have been treating for 10 years had not responded to one medication until she took Viagra, whereupon she felt almost normal. Nitroglycerin and hydralazine, which stimulate cyclic GMP by different mechanisms, had not helped her
no, not at all. I took it a lot of times before intercourse (not on a daily basis) and I felt no improvement over fatigue or any other symptoms.
6 controls, 6 viagra. Increasing dose of viagra until 6 weeks. 1 Viagra dropped out and could not be contacted. Trial for cerebral blood flow and fatigue in Chronic Fatigue Syndrome. Primary outcome self reported fatigue after 6 weeks (using a 42 question fatigue impact score 0-142). No info on fatigue score averages at baseline. Placebo outcome was -1.5, Viagra outcome was -33. p<.05. Possibly the variance is high though, because the SD is high.