Jackb23
Senior Member
- Messages
- 293
- Location
- Columbus, Ohio
While there are several compounds that have been found to inhibit IDO-1 and/or IDO2, these decrease both the neurotoxic and neuroprotective byproducts within the Kynurenine Pathway (KYNA is Neuroprotective and beneficial in other ways too).
NCR-631 is an inhibitor of 3-hydroxyanthranilic acid dioxygenase which is the last enzyme involved before Quinolinic Acid is formed (Neurotoxic NMDA agonist and Glutamate reuptake inhibitor, amongst other things). After doing some research today, I read that the Kynurenine pathway imposes it’s effects more through glial cells than neurally.
Question now is where can someone find NCR-631.
If through a lab, fabrication of one’s credentials would likely be needed and I don’t think you’d be able to get enough to last. Would also be very expensive.
Don’t know if there is a specific .onion website for research compounds on Tor, but even if there is, the dark web can be a icky place.
Abstract for what I referenced above:
https://www.ncbi.nlm.nih.gov/m/pubmed/11026503/
NCR-631 is an inhibitor of 3-hydroxyanthranilic acid dioxygenase which is the last enzyme involved before Quinolinic Acid is formed (Neurotoxic NMDA agonist and Glutamate reuptake inhibitor, amongst other things). After doing some research today, I read that the Kynurenine pathway imposes it’s effects more through glial cells than neurally.
Question now is where can someone find NCR-631.
If through a lab, fabrication of one’s credentials would likely be needed and I don’t think you’d be able to get enough to last. Would also be very expensive.
Don’t know if there is a specific .onion website for research compounds on Tor, but even if there is, the dark web can be a icky place.
Abstract for what I referenced above:
https://www.ncbi.nlm.nih.gov/m/pubmed/11026503/