Amanita Muscaria micro-dosing experience

Messages
15
Hi all, it's been a long time since I last posted, mostly because there was nothing interesting to report. Well, now there is.

Tl;dr: I've been micro-dosing Amanita Muscaria (fly agaric) mushroom for about two months and it helps me with energy and drowsiness (and possibly mood/anxiety, albeit that could be indirect result of previous two)

A bit about my story: under-diagnosed, with me and some doctors suspecting CFS, but never confirmed; I was also suspected for depression and autism, but again didn't pursue proper diagnosis (at one point some antidepressant was a bit helpful, though not as drastic as the topic); in any case I've been mild most of the time; and whatever issues I had they mostly progressed slowly without noticeable onset points (well, I could probably retroactively find one or two, but they weren't as decisive as often described, and this post is already long enough); used to have very annoying (albeit not very interesting to most doctors) digestive symptoms which have largely gone away after anti-parasitic treatment (~2 years ago?). This likely improved systemic symptoms as well, but didn't eliminate them. Sleep still remained not refreshing enough, which was my main easy to describe complaint (and I felt like everything else stemmed from it, which might just be convenient mistake). So with many other life issues I've been going through I largely stopped seeking new treatments for myself, rotating through various sleep aids and falling asleep technics.

However, sometime late winter/early spring this year I've had some infection (likely COVID but could've been that new strain of flu people were talking about) which lead to the worst first person CFS-like experience in my life. For over a month — sometimes it would fade away to the point I thought I recovered, sometimes it would return — I've regularly had fever, almost constant brain fog, fatigue, spent most days in bed unable to do anything productive most of the time (still could prepare basic food, but it wasn't a piece of cake) — in other words nothing serious compared to many people here; knowing quite some info on CFS I was already preparing to spend the rest of my life like that — luckily I wasn't taken by complete suprise and luckily I didn't lose my sense of humour. But for whatever reason — more luck? — it passed anyway, without any specific intervention (except that I mostly wasn't pushing myself). But I've wasted a lot of time (and money), got somewhat scared that indeed I'm not magically protected from getting much worse, so started to look for treatments again (or less poetically I simply wanted to get myself in shape to earn enough money).

I'll skip a few details for brevity, but somehow I stumbled upon Amanita Muscaria (aka fly agaric), which was advertised as basically a magic pill: allegedly helps with sleep, fatigue, mood, depression, anxiety along many other things — and decided to try it; primarily hoping to get pleasant refreshing sleep — which ironically is something I didn't quite achieve, — I bought 100g and started micro-dosing (note that it turns out either I was scammed and there wasn't 100g there, or the mushroom wasn't potent enough, or I have high tolerance to it; but the doses I've been taking seem significantly higher than those usually advertised and didn't lead to any sort of "trip" that is said to occur at larger doses; even when I tried to find the threshold dose I had to keep eating the mushroom during the day only to get very mild dissociative effect (*) (but still I wouldn't recommend doing that to anybody with significant CFS symptoms). In any case, I've been taking like a few grams every day and after some time (a week, maybe?) started noticing its effects. I didn't get noticeable subjective improvement in sleep quality (some nights even getting some of the brightest nightmares), but somehow started feeling less under-slept during the day and recovered much quicker from that terrible state after waking up (these days, I can get to daytime baseline in like a couple minutes compared to what was like a couple hours). The weather kept getting better, too (and warm days tend to go much easier on me), so naturally I didn't take it for granted that it's mushroom's work. Still, I continued to take it to see whether it's placebo or real; started to work on things I've been putting away for months; noticed that alcohol is becoming to affect me much less (which was sad cause it was one of easy to get substances to "take off the edge"), and nicotine almost completely losing its effects (which was mostly good cause I started to smoke too much in the period before and lacking any rewards it was trivial to stop — note however that I was never properly hard smoker, so YMMV), confirming bioactivity of the mushroom; and soon I got final confirmation: when my batch ended, the positive changes were soon to fade away. Naturally I grabbed more (from a different source, so any theories of first batch containing other substances that actually helped went away too) and soon the effects returned.

At the point of writing I don't feel like 100% normal healthy human being, but much closer to that than I felt in years. I realize however that I might have just been very lucky and it's quite possible my health issues is something else undiagnosed and not proper CFS. Still, I think it might be worth trying to more people here, provided you take necessary precautions and don't have too high expectations. Hence I decided to share my experience.

(*): loosely speaking I felt as though I'm observing my flow of thoughts and subconsciousness from a distance, virtually not "feeling" any emotions I was "experiencing", as well as — perhaps more interestingly to people here and the only reason I've even bothered describing this — having much easier access to memory, being able to recall random childhood episodes with significant clarity and even a complete verse I wrote about five years ago that I previously was trying to recall quite unsuccessfully couple times. Still, I mention this not to recommend experimenting with large doses to anyone here — in fact I should mention that however mild this experience was I got somewhat close to experiencing unmotivated raw paranoia, — but rather to suggest that even micro-dosing might positively affect memory even if it's less noticeable effect.

(**): conflict of interest statement: at the time of writing I haven't harvested or sold single fly agaric mushroom, nor am I payed to advertise them

PS: sorry if my writing is a bit stream of consciousness like, feel free to ask to clarify or any other questions.

PPS: unlike some other mushrooms, fly agaric is legal in most (albeit not all) countries
 

DonPepe

Senior Member
Messages
183
Hi all, it's been a long time since I last posted, mostly because there was nothing interesting to report. Well, now there is.

Tl;dr: I've been micro-dosing Amanita Muscaria (fly agaric) mushroom for about two months and it helps me with energy and drowsiness (and possibly mood/anxiety, albeit that could be indirect result of previous two)

A bit about my story: under-diagnosed, with me and some doctors suspecting CFS, but never confirmed; I was also suspected for depression and autism, but again didn't pursue proper diagnosis (at one point some antidepressant was a bit helpful, though not as drastic as the topic); in any case I've been mild most of the time; and whatever issues I had they mostly progressed slowly without noticeable onset points (well, I could probably retroactively find one or two, but they weren't as decisive as often described, and this post is already long enough); used to have very annoying (albeit not very interesting to most doctors) digestive symptoms which have largely gone away after anti-parasitic treatment (~2 years ago?). This likely improved systemic symptoms as well, but didn't eliminate them. Sleep still remained not refreshing enough, which was my main easy to describe complaint (and I felt like everything else stemmed from it, which might just be convenient mistake). So with many other life issues I've been going through I largely stopped seeking new treatments for myself, rotating through various sleep aids and falling asleep technics.

However, sometime late winter/early spring this year I've had some infection (likely COVID but could've been that new strain of flu people were talking about) which lead to the worst first person CFS-like experience in my life. For over a month — sometimes it would fade away to the point I thought I recovered, sometimes it would return — I've regularly had fever, almost constant brain fog, fatigue, spent most days in bed unable to do anything productive most of the time (still could prepare basic food, but it wasn't a piece of cake) — in other words nothing serious compared to many people here; knowing quite some info on CFS I was already preparing to spend the rest of my life like that — luckily I wasn't taken by complete suprise and luckily I didn't lose my sense of humour. But for whatever reason — more luck? — it passed anyway, without any specific intervention (except that I mostly wasn't pushing myself). But I've wasted a lot of time (and money), got somewhat scared that indeed I'm not magically protected from getting much worse, so started to look for treatments again (or less poetically I simply wanted to get myself in shape to earn enough money).

I'll skip a few details for brevity, but somehow I stumbled upon Amanita Muscaria (aka fly agaric), which was advertised as basically a magic pill: allegedly helps with sleep, fatigue, mood, depression, anxiety along many other things — and decided to try it; primarily hoping to get pleasant refreshing sleep — which ironically is something I didn't quite achieve, — I bought 100g and started micro-dosing (note that it turns out either I was scammed and there wasn't 100g there, or the mushroom wasn't potent enough, or I have high tolerance to it; but the doses I've been taking seem significantly higher than those usually advertised and didn't lead to any sort of "trip" that is said to occur at larger doses; even when I tried to find the threshold dose I had to keep eating the mushroom during the day only to get very mild dissociative effect (*) (but still I wouldn't recommend doing that to anybody with significant CFS symptoms). In any case, I've been taking like a few grams every day and after some time (a week, maybe?) started noticing its effects. I didn't get noticeable subjective improvement in sleep quality (some nights even getting some of the brightest nightmares), but somehow started feeling less under-slept during the day and recovered much quicker from that terrible state after waking up (these days, I can get to daytime baseline in like a couple minutes compared to what was like a couple hours). The weather kept getting better, too (and warm days tend to go much easier on me), so naturally I didn't take it for granted that it's mushroom's work. Still, I continued to take it to see whether it's placebo or real; started to work on things I've been putting away for months; noticed that alcohol is becoming to affect me much less (which was sad cause it was one of easy to get substances to "take off the edge"), and nicotine almost completely losing its effects (which was mostly good cause I started to smoke too much in the period before and lacking any rewards it was trivial to stop — note however that I was never properly hard smoker, so YMMV), confirming bioactivity of the mushroom; and soon I got final confirmation: when my batch ended, the positive changes were soon to fade away. Naturally I grabbed more (from a different source, so any theories of first batch containing other substances that actually helped went away too) and soon the effects returned.

At the point of writing I don't feel like 100% normal healthy human being, but much closer to that than I felt in years. I realize however that I might have just been very lucky and it's quite possible my health issues is something else undiagnosed and not proper CFS. Still, I think it might be worth trying to more people here, provided you take necessary precautions and don't have too high expectations. Hence I decided to share my experience.

(*): loosely speaking I felt as though I'm observing my flow of thoughts and subconsciousness from a distance, virtually not "feeling" any emotions I was "experiencing", as well as — perhaps more interestingly to people here and the only reason I've even bothered describing this — having much easier access to memory, being able to recall random childhood episodes with significant clarity and even a complete verse I wrote about five years ago that I previously was trying to recall quite unsuccessfully couple times. Still, I mention this not to recommend experimenting with large doses to anyone here — in fact I should mention that however mild this experience was I got somewhat close to experiencing unmotivated raw paranoia, — but rather to suggest that even micro-dosing might positively affect memory even if it's less noticeable effect.

(**): conflict of interest statement: at the time of writing I haven't harvested or sold single fly agaric mushroom, nor am I payed to advertise them

PS: sorry if my writing is a bit stream of consciousness like, feel free to ask to clarify or any other questions.

PPS: unlike some other mushrooms, fly agaric is legal in most (albeit not all) countries
This is very interesting. I have recently been looking into mushrooms and their effects on Gaba. Especially the type you’ve mentioned, Amanita Muscaria

Here is what AI has to say about it …

Amanita muscaria, also known as the fly agaric mushroom, has several medicinal properties that have been explored for centuries. The main psychoactive compounds found in this mushroom are muscimol and ibotenic acid, which interact with the brain's GABA receptors to produce various effects. Here are some of the potential medicinal benefits of Amanita muscaria:

1. **Anxiety and Stress Relief**: Muscimol in Amanita muscaria can help alleviate symptoms of anxiety, PTSD, and stress by interacting with glutamate receptors in the brain. It is known for its calming and relaxing effects, often compared to the body-high effects of Cannabis Indica[1][2].

2. **Depression**: The muscimol in Amanita muscaria can promote calmness, relaxation, and the easing of stress and its symptoms, which can help alleviate depression. It stimulates GABA receptors in the mind, influencing rest and mood[1].

3. **Creativity and Cognitive Function**: Amanita muscaria is believed to enhance creativity and cognitive function due to its psychoactive properties. It is often used in micro-dosing to improve focus, mood, and overall well-being[1][4].

4. **Anti-Inflammatory Effects**: The compounds in Amanita muscaria have been found to interact with GABA receptors, which influence the body's inflammatory response. This property can help alleviate discomfort caused by inflammation[1].

5. **Substance Abuse Treatment**: Amanita muscaria has been observed to decrease cravings for alcohol due to the normalization of the psychological background and the direct competition of muscimol with ethanol for the GABA receptors of the brain[4].

It is essential to note that while these medicinal properties are promising, Amanita muscaria can be toxic if not properly prepared. It is crucial to approach the use of this mushroom with caution and respect, ensuring proper processing and dosing to avoid adverse effects[1][3][4].

Sources
[1] The Potential Benefits Of Amanita Muscaria Mushrooms - Exhale Well https://www.exhalewell.com/blog/potential-benefits-of-amanita/
[2] The Medicinal Properties Of Fly Agaric (Amanita Mushrooms) https://cleanremedies.com/blogs/cbd-basics/muscimol-benefits
[3] Amanita muscaria - Wikipedia https://en.wikipedia.org/wiki/Amanita_muscaria
[4] Amanita Muscaria: What is it and how can it help? https://bloomable.ca/blogs/news/amantia-muscaria-what-is-it-and-how-can-it-help
[5] Amanita muscaria - an overview | ScienceDirect Topics https://www.sciencedirect.com/topic...y-and-pharmaceutical-science/amanita-muscaria



On paper it seems the perfect drug to ease CFS. But things with ME are never that simple. I’m pleased you’ve got relief. If I could access a supply I’d give it a whirl.
 

mattie

Senior Member
Messages
384
The safety of consuming Amanita muscaria, even at low doses, is a contentious topic. While some individuals and traditional practices may consider low doses to be relatively safe, this does not eliminate the inherent risks associated with its use. Here are some key points to consider:

1. **Variable Potency**: The concentration of toxic compounds in Amanita muscaria can vary widely depending on factors such as the mushroom's age, environment, and preparation method. This makes it difficult to standardize a "safe" low dose.

2. **Unpredictable Effects**: Even at low doses, the effects of muscimol and ibotenic acid can be unpredictable. Some individuals may experience mild effects, while others could have more severe reactions, including gastrointestinal distress, dizziness, and hallucinations.

3. **Potential for Cumulative Toxicity**: Repeated use, even at low doses, may lead to cumulative toxicity or adverse health effects over time.

4. **Lack of Clinical Research**: There is limited clinical research on the safety and efficacy of using Amanita muscaria for medicinal purposes. Most evidence is anecdotal or comes from traditional practices, which may not align with modern safety standards.

5. **Safer Alternatives**: For many of the conditions or effects sought through Amanita muscaria, there are safer and more thoroughly researched alternatives available.

If considering the use of Amanita muscaria, it is crucial to proceed with extreme caution, ideally under the guidance of a knowledgeable healthcare professional or expert in ethnobotany. It is important to weigh the potential benefits against the risks and to be fully informed about the possible consequences.
 

DonPepe

Senior Member
Messages
183
The safety of consuming Amanita muscaria, even at low doses, is a contentious topic. While some individuals and traditional practices may consider low doses to be relatively safe, this does not eliminate the inherent risks associated with its use. Here are some key points to consider:

1. **Variable Potency**: The concentration of toxic compounds in Amanita muscaria can vary widely depending on factors such as the mushroom's age, environment, and preparation method. This makes it difficult to standardize a "safe" low dose.

2. **Unpredictable Effects**: Even at low doses, the effects of muscimol and ibotenic acid can be unpredictable. Some individuals may experience mild effects, while others could have more severe reactions, including gastrointestinal distress, dizziness, and hallucinations.

3. **Potential for Cumulative Toxicity**: Repeated use, even at low doses, may lead to cumulative toxicity or adverse health effects over time.

4. **Lack of Clinical Research**: There is limited clinical research on the safety and efficacy of using Amanita muscaria for medicinal purposes. Most evidence is anecdotal or comes from traditional practices, which may not align with modern safety standards.

5. **Safer Alternatives**: For many of the conditions or effects sought through Amanita muscaria, there are safer and more thoroughly researched alternatives available.

If considering the use of Amanita muscaria, it is crucial to proceed with extreme caution, ideally under the guidance of a knowledgeable healthcare professional or expert in ethnobotany. It is important to weigh the potential benefits against the risks and to be fully informed about the possible consequences.
Of course caution is needed trying any drug.

In recent times the potential medicinal benefits from fungi have been been taken a lot more seriously, especially for use in depression and bi-polar.

Being very severe and all must out of hope, I may try it after my current regimen.
 
Last edited:
Messages
15
The safety of consuming Amanita muscaria, even at low doses, is a contentious topic. While some individuals and traditional practices may consider low doses to be relatively safe, this does not eliminate the inherent risks associated with its use. Here are some key points to consider:
Is this written by LLM (GPT etc)? If so please mark it as such. While the concerns are generally valid, some seem a bit misplaced here.
1. **Variable Potency**: The concentration of toxic compounds in Amanita muscaria can vary widely depending on factors such as the mushroom's age, environment, and preparation method. This makes it difficult to standardize a "safe" low dose.
Yep. It's always good to have an access to a lab, unfortunately it's hard to procure for most of us.
One way to somewhat alleviate this is to use ground mixed caps and weight each dose (or buy ready-made capsules from a trustworthy source, if available). Then you only need to titrate each batch.
2. **Unpredictable Effects**: Even at low doses, the effects of muscimol and ibotenic acid can be unpredictable. Some individuals may experience mild effects, while others could have more severe reactions, including gastrointestinal distress, dizziness, and hallucinations.
This seems to be true for all potent substances. Especially considering many people here have otherwise rare sensitivities.
3. **Potential for Cumulative Toxicity**: Repeated use, even at low doses, may lead to cumulative toxicity or adverse health effects over time.
I wonder if it's based on some research or just a general precaution. From what I gather active chemicals are not supposed to be stuck in body, and if properly prepared ibotenic acid concentration should be too low to slowly degrade liver or whatnot. That said, these mushrooms are said to overaccumulate vanadium (https://www.sciencedirect.com/science/article/abs/pii/S0162013400000349)
4. **Lack of Clinical Research**: There is limited clinical research on the safety and efficacy of using Amanita muscaria for medicinal purposes. Most evidence is anecdotal or comes from traditional practices, which may not align with modern safety standards.

5. **Safer Alternatives**: For many of the conditions or effects sought through Amanita muscaria, there are safer and more thoroughly researched alternatives available.
This seems a bit inapplicable here as we wouldn't be looking for experimental treatments if there would be a well-researched effective one..

Anyway, I'd encourage everyone who want to try it to do their own research and consult with doctor(s) if available. It would be nice to read some papers, which I must admit I mostly skipped, maybe reading through abstract or two.
 
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