https://newatlas.com/aging/biological-aging-brain-cells/
It's a study using new technologies to map brain cells.
"The researchers found that it was mostly glial cells, a class of cells that support, connect, and protect the brain’s neurons, that showed significant age-related changes to gene expression. Strongly affected were immune system-related cells (microglia, oligodendrocytes, and border-associated macrophages (BAMs)) and specialized glial cells called tanycytes and ependymal cells."
"Specifically, the researchers found increased expression of inflammatory and immune response genes in these cells and decreased expression of genes relating to neuron signaling and structure. The most significant changes were in cells near the hypothalamus’ third ventricle (V3), critical to regulating vital physiological and behavioral processes, including temperature, hunger and satiety, thirst and fluid balance, sleep-wake cycles, and circadian rhythms."
Maybe this sort of mapping for PWME might show something? ME isn't limited to mature humans, but maybe some of these changes in gene expression can occur in children.
These sorts of changes fits my theory of feedback loops changing parameters and ending up locking into a state. It's like a resistor in an amplifier changing resistance with age, changing the feedback function. If one gene results in a stronger response to an infection, and the gene controlling the counter-response weakens, then it's plausible for infections to trigger a change in state.
It's a study using new technologies to map brain cells.
"The researchers found that it was mostly glial cells, a class of cells that support, connect, and protect the brain’s neurons, that showed significant age-related changes to gene expression. Strongly affected were immune system-related cells (microglia, oligodendrocytes, and border-associated macrophages (BAMs)) and specialized glial cells called tanycytes and ependymal cells."
"Specifically, the researchers found increased expression of inflammatory and immune response genes in these cells and decreased expression of genes relating to neuron signaling and structure. The most significant changes were in cells near the hypothalamus’ third ventricle (V3), critical to regulating vital physiological and behavioral processes, including temperature, hunger and satiety, thirst and fluid balance, sleep-wake cycles, and circadian rhythms."
Maybe this sort of mapping for PWME might show something? ME isn't limited to mature humans, but maybe some of these changes in gene expression can occur in children.
These sorts of changes fits my theory of feedback loops changing parameters and ending up locking into a state. It's like a resistor in an amplifier changing resistance with age, changing the feedback function. If one gene results in a stronger response to an infection, and the gene controlling the counter-response weakens, then it's plausible for infections to trigger a change in state.
