SWAlexander
Senior Member
- Messages
- 2,076
Purpose
In an ongoing study of oxidative stress and the effect of CoenzymeQ10 (CoQ10) at Bragée ME-Center in Stockholm, Sweden, incident and type of adverse effects were studied.
Method
Information of adverse effects were collected in three ways: 1: Study participants ending the study due to adverse effects. 2: Video consultations during the 12 weeks study where changes of symptoms and adverse effects were asked for. 3: At the end of the study the principal investigator (PI) asked for the occurrence of adverse effects.
Results
14 patients (11,7%) ended the study due to adverse effects. Most severe adverse effect was depression. During video visits 300 occurrences of changing symptoms/adverse effects were recorded. Most common were insomnia, headache and gastroenteric dysfunction. At the visit to the PI at the end of the study 47 participants reported adverse effects, most commonly mild reactions such as rashes, insomnia and gastrointestinal symptoms. More severe adverse effects reported were palpitations, depression, headache, and anxiety.
Conclusion
Adverse effects when taking CoQ10 seem to be common. Most often the symptoms are mild. Gastrointestinal symptoms, rashes and insomnia were common. A more severe adverse reaction was depression which previously has not been described.
https://www.researchsquare.com/article/rs-5362194/v1
