nanonug
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1. Stem Cells. 2010 Nov;28(11):2065-72. doi: 10.1002/stem.523.
Adipose tissue as a dedicated reservoir of functional mast cell progenitors.
Poglio S, De Toni-Costes F, Arnaud E, Laharrague P, Espinosa E, Casteilla L,
Cousin B.
CNRS, UMR 5241 Métabolisme, Plasticité et Mitochondrie, Université de Toulouse
III Paul Sabatier, Toulouse, France.
White adipose tissue (WAT) is a heterogeneous tissue, found in various locations
throughout the body, containing mature adipocytes and the stroma-vascular
fraction (SVF). The SVF includes a large proportion of immune hematopoietic
cells, among which, mast cells that contribute to diet-induced obesity. In this
study, we asked whether mast cells present in mice adipose tissue could derive
from hematopoietic stem/progenitor cells (HSPC) identified in the tissue. We
therefore performed both in vitro and in vivo experiments dedicated to monitoring
the progeny of WAT-derived HSPC. The entire study was conducted in parallel with
bone marrow-derived cells, considered the gold standard for hematopoietic-lineage
studies. Here, we demonstrate that adipose-derived HSPC contain a precursor-cell
population committed to the mast cell lineage, and able to efficiently home to
peripheral organs such as intestine and skin, where it acquires properties of
functional tissue mast cells. Additionally, WAT contains a significant mast cell
progenitor population, suggesting that the entire mast cell lineage process take
place in WAT. Considering the quantitative importance of WAT in the adult
organism and the increasing roles recently assigned to mast cells in
physiopathology, WAT may represent an important source of mast cells in
physiological and pathological situations.
Copyright © 2010 AlphaMed Press.
PMID: 20845475
Adipose tissue as a dedicated reservoir of functional mast cell progenitors.
Poglio S, De Toni-Costes F, Arnaud E, Laharrague P, Espinosa E, Casteilla L,
Cousin B.
CNRS, UMR 5241 Métabolisme, Plasticité et Mitochondrie, Université de Toulouse
III Paul Sabatier, Toulouse, France.
White adipose tissue (WAT) is a heterogeneous tissue, found in various locations
throughout the body, containing mature adipocytes and the stroma-vascular
fraction (SVF). The SVF includes a large proportion of immune hematopoietic
cells, among which, mast cells that contribute to diet-induced obesity. In this
study, we asked whether mast cells present in mice adipose tissue could derive
from hematopoietic stem/progenitor cells (HSPC) identified in the tissue. We
therefore performed both in vitro and in vivo experiments dedicated to monitoring
the progeny of WAT-derived HSPC. The entire study was conducted in parallel with
bone marrow-derived cells, considered the gold standard for hematopoietic-lineage
studies. Here, we demonstrate that adipose-derived HSPC contain a precursor-cell
population committed to the mast cell lineage, and able to efficiently home to
peripheral organs such as intestine and skin, where it acquires properties of
functional tissue mast cells. Additionally, WAT contains a significant mast cell
progenitor population, suggesting that the entire mast cell lineage process take
place in WAT. Considering the quantitative importance of WAT in the adult
organism and the increasing roles recently assigned to mast cells in
physiopathology, WAT may represent an important source of mast cells in
physiological and pathological situations.
Copyright © 2010 AlphaMed Press.
PMID: 20845475