Accelerating discovery: A novel flow cytometric method for detecting fibrin(ogen) amyloid microclots using long COVID as a model

[SWAlexander]

Highlights​

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  Imaging flow cytometry utilizing a novel rapid flow cytometric detection method is a promising method for detecting amyloid fibrin(ogen) microclots in conditions associated with clotting pathology.
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  While this investigation represents a preliminary study, it lays the foundation for further research into the method's utility as a diagnostic tool for individuals with Long COVID.
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  Though challenging, future research can explore potential correlations between microclot detection and specific Long COVID symptoms and comorbidities, enhancing our understanding of the pathophysiology and tools to detect this condition.
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  The method's ability to evaluate amyloid microclot presence, concentration, and size offers valuable insights for clinical applications.

https://www.sciencedirect.com/science/article/pii/S2405844023068135

I ask, is there really anything new?

 

[SWAlexander]

Fibrin drives thromboinflammation and neuropathology in COVID-19

Excerpt: Here we show that fibrin binds to the SARS-CoV-2 spike protein, forming proinflammatory blood clots that drive systemic thromboinflammation and neuropathology in COVID-19. Fibrin, acting through its inflammatory domain, is required for oxidative stress and macrophage activation in the lungs, whereas it suppresses natural killer cells, after SARS-CoV-2 infection. https://www.nature.com/articles/s41586-024-07873-4