B6 / p5p problems...
This thread is meant to discuss the experiences of ME patients with high doses of the separate b vitamins. It is NOT a methylation thread, therefore I posted it on the general treatment section.
Many supplements nowadays include high doses of the b-vits. The arguement is that, as they are soluble, more cant hurt.
Unfortunately this is not true. I got neuropathy from the soluble b6, and even its 'harmless' form of p5p, and im not the only one
For an excellent overview of the effects of high doses of the B's see
http://www.acu-cell.com/bx.html
I know for me that high b12 and b6 is not good, and worsens numbness. I dont think high dose niacinamide, pantethine helped me. I think high dose thiamin and biotin might be good. Not sure about riboflavin. WHat are your experiences?
Hi Leaves,
Long time no "talk".
I've had similar problems, at least in the last nine months or so, with some of the b vitamins, but it's always SO hard to tell what is really making something worse and what isn't. I've tried p5p by itself, and in a combo with tryptophan, and I THINK it gave me considerably more tingling and numbness...although I stopped it after 2 or 3 days, so not certain on that.
Other's have said that indeed, riboflavin (B2) can help with neuropathy from b6/p5p:
http://onibasu.com/archives/am/201265.html
And I haven't tried this directly yet, but have you tried taking magnesium with the b6 or p5p?
According to Rosemary Waring,
p5p INHIBITS the PST/sulfation pathway, so sals, phenols, etc., build up, but by adding an equal amount of magnesium, this inhibition goes away:
"Dr. Warings results confirm what ARI had first reported in 1973: whenever extra vitamin B6 is given, it must be accompanied by extra magnesium, or adverse effects may be seen. In our first study of vitamin B6 in autistic children, conducted in the late 1960s, a small number of the autistic children in the experiment showed increased sound sensitivity, irritability and enuresis when the B6 was started.
When magnesium was added, these side effects immediately disappeared and the beneficial effects of the B6 were enhanced. Several studies by the research team led by Dr. Gilbert LeLord of Tours University Medical School, in France, confirmed our report that the combination of vitamin B6 and magnesium was markedly more effective than either vitamin B6 or magnesium alone."
The studies are also listed on the same page:
http://legacy.autism.com/medical/research/drwaringstudy.htm
And then there's another mention on this page:
http://www.allnaturaladvantage.com.au/Phenol Sensitivity.htm
"Vitamin B6 and/or P-5-P can aggravate the PST problem of some children (and adults I'm assuming), by making it difficult for the child to process phenols. B6 in the form of P5P (pyridoxal-5-phosphate) inhibits PST (phenol sulphur-transferase) activity. This could be why some children show adverse effects when supplements high in P5P are started. However the same study showed that increasing magnesium supplementation reverses this inhibition. ARI got Dr Rosemary Waring to do the research that showed that B6 can inhibit human sulfotransferases, but they are activated by magnesium so that if you have at least a 1:1 mix of B6:Mg there is no problem. This is why, if you have a problem with B6, try to see if taking magnesium will help."
And then finally, I wonder if one is deficient in zinc (which I am...and probably copper toxic) if that's perhaps a reason why we have reactions to b6 or p5p? A website on pyroluria said that zinc is required for the conversion to p5p...and so if we're low, perhaps it doesn't get "completely" converted or utilized properly???
Just my two cents...still trying to figure this out.
Hope you're having some 'better' days?
Dan