It is interesting how often 'chronic fatigue' is used in place of CFS. IMHO, the only reason there is unclear treatments is because there is no valid scientific research looking for contributing factors; there is only an assumption of psychological factors, not born out by double-blinded control studies. It is not acknowledged that even if a PWC/ME is depressed, they many times are adversely affected by the doses required to treat it, solely because of the underlying CFS/ME. This is all psychobabble to me.