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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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tryptophan

  1. C

    The Role of Kynurenine Pathway and NAD+ Metabolism in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (Dehhaghi et al, 2022)

    Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious, complex, and highly debilitating long-term illness. People with ME/CFS are typically unable to carry out their routine activities. Key hallmarks of the disease are neurological and gastrointestinal impairments...
  2. Joel98

    Can I try 5-HTP despite the possible Metabolic Trap without irreversibly worsening it?!

    Hello, I'm wondering if I can test 5-HTP capsules without worsening the possible Metabolic Trap. If I understand it correctly, it is still unclear whether you have too much or too little serotonin as a result. My symptoms tend to feel like too little and a urine test (which I know has little...
  3. C

    Too Much Serotonin

    So I am pretty sure that I have a major problem with too much serotonin. I have almost every symptom of serotonin syndrome. It seems to go into overdrive with any stressor of any type. When I crash from exertion or get triggered by a stressor, my neck and face get red. My muscles tense...
  4. nerd

    Bacterial neurotoxic metabolites in multiple sclerosis cerebrospinal fluid and plasma

    Authors: Achilles Ntranos, Hye-Jin Park, Maureen Wentling, Vladimir Tolstikov, Mario Amatruda, Benjamin Inbar, Seunghee Kim-Schulze, Carol Frazier, Judy Button, Michael A Kiebish, Fred Lublin, Keith Edwards, Patrizia Casaccia Published on: December 11, 2021 doi: 10.1093/brain/awab320 Abstract
    • nerd
    • Thread
    • csf ido metabolic trap microbiome microbiota multiple sclerosis neurotoxicity phenylalanine tryptophan
    • Replies: 2
    • Forum: Other Health News and Research
  5. nerd

    Brain Kynurenine and BH4 Pathways: Relevance to the Pathophysiology and Treatment of Inflammation-Driven Depressive Symptoms

    Vancassel S, Capuron L and Castanon N (2018) Brain Kynurenine and BH4 Pathways: Relevance to the Pathophysiology and Treatment of Inflammation-Driven Depressive Symptoms. Front. Neurosci. 12:499. doi: 10.3389/fnins.2018.00499 Abstract How is this relevant? One of the unsolved questions of...