tolerance

  1. sb4

    In states of chronic stress why does the bodies receptors not become tolerant to things like norepinephrine, yet when taking medications it does?

    I have noticed that when taking clonidine it alleviates a bunch of my symptoms, however after a relatively short period of time it stops working. This is presumably due to the receptors it works on (alpha adrenergic 2 receptors) downregulating in response to overstimulation. Why doesn't this...
  2. frozenborderline

    Agmatine and memantine--risks of combining?

    I use both agmatine and memantine to keep opioid tolerance reasonable or low. And to prevent hyperalgesia. (I also use ultra low dose naltrexone at the same time but I dont think that has any interactions) Memantine has fairly well documented mechanism of action and side effects and human...
Back