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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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    Does the Low Dose Naltrexone mechanism extend to other drugs?

    LDN works by transient antagonism of the opioid receptors, thereby tricking the body to upregulate them. Recently, I started taking a low dose of Clonidine for sleep. Clonidine binds to presynaptic alpha2 receptors, reducing adrenaline release. However, during the day I started having random...