clonidine

  1. sb4

    In states of chronic stress why does the bodies receptors not become tolerant to things like norepinephrine, yet when taking medications it does?

    I have noticed that when taking clonidine it alleviates a bunch of my symptoms, however after a relatively short period of time it stops working. This is presumably due to the receptors it works on (alpha adrenergic 2 receptors) downregulating in response to overstimulation. Why doesn't this...
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