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Zinn, Zinn, Jason: Functional Neural Network Connectivity in Myalgic Encephalomyelitis

Discussion in 'Latest ME/CFS Research' started by mango, Mar 8, 2016.

  1. mango

    mango Senior Member

    Functional Neural Network Connectivity in Myalgic Encephalomyelitis.

    Zinn, M. L., Zinn, M. A., & Jason, L. A. (2016).

    NeuroRegulation, 3(1), 28–50.

    Myalgic Encephalomyelitis (ME) is a chronic illness with debilitating neurocognitive impairment that remains poorly understood.

    Previous studies have characterized cognitive deficits as a process by which brain abnormalities are inferred from pre-established testing paradigms using neuroimaging with low temporal
    resolution. Unfortunately, this approach has been shown to provide limited predictive power, rendering it inadequate for the study of neuronal communication between synchronized regions.

    More recent developments have highlighted the importance of modeling spatiotemporal dynamic interactions within and between large-scale and small-scale neural networks on a millisecond time scale.

    Here, we focus on recent emergent principles of complex cortical systems, suggesting how subtle disruptions of network properties could be related to significant disruptions in cognition and behavior found in ME.

    This review, therefore, discusses how electrical neuroimaging methods with time-dependent metrics (e.g., coherence, phase, cross-frequency coupling) can be a useful approach for the understanding of the cognitive symptoms in ME.

    By providing a platform for utilizing real-time alterations of the perpetual signals as an outcome, the disruptions to higher-level cognition typically seen in ME can be readily identified, creating new opportunities for better diagnosis and targeted treatments.

    jimells likes this.
  2. mango

    mango Senior Member

  3. sdmcvicar


    I've seen several links to articles with Dr. Jason as one of the authors. His bibliography on ResearchGate shows that he is extremely prolific, and I know of his academic appointment and qualifications. However, aside from a case study, everything I have seen from him is either a review or opinion article. Does anyone know if his laboratory publishes (continues to publish?) any primary research? Or is he mostly theoretical, designing frameworks for testing and interpreting data from other groups?
  4. taniaaust1

    taniaaust1 Senior Member

    Sth Australia
    He's done a lot of studies in which weren't reviews or opinion articles. I suggest to go to pubmed and look up what studies he's done.
  5. JaimeS

    JaimeS Senior Member

    Silicon Valley, CA
    It's a good review article, very logical and well laid-out. The intro gives the impression of being completely unbiased, which is pretty rare!


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