• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To become a member, simply click the Register button at the top right.

Younger: Daily Fluctuations of Progesterone and Testosterone are Associated with Fibromyalgia Pain

E

Ema

Senior Member
Messages
4,729
Location
Midwest USA
The purpose of this longitudinal blood sampling study was to examine relationships between sex hormones and fibromyalgia pain. Eight women meeting case definition criteria for fibromyalgia provided venous blood samples and reported their fibromyalgia pain severity over 25 consecutive days. All women exhibited normal menstrual cycles and were not taking oral contraceptives.

Cortisol, and the sex hormones estradiol, progesterone, and testosterone, were assayed from serum.

A linear mixed model was used to determine if fluctuations of sex hormones were associated with changes in pain severity.

In the entire sample, day-to-day changes in both progesterone (p = 0.002) and testosterone (p = 0.015) were significantly and inversely correlated with pain severity. There was no relationship between estradiol and pain (p = 0.551) or cortisol and pain (p = 0.633).

These results suggest that progesterone and testosterone play a protective role in fibromyalgia pain severity. Sex and other hormones may serve to both increase and decrease fibromyalgia pain severity.
Click to expand...


Full text here: http://www.jpain.org/article/S1526-5900(17)30804-0/fulltext
 
You must log in or register to reply here.