Hi, I have been supplementing with a customised mix of vitamins and supplements based on my Yasko SNP results, as well as my Metamatrix results (which tie up very well to the SNP results). In addition, I have been on the 8th blood wash and have also undergone EDTA and DMSA chelation. All metals are out, apart from some residual Aluminium and Nickel. I still have 2 more EDTA/DMSA sessions to go and in parallel, I started taking Malic Acid to address the residual aluminium. Nevertheless, I do not seem to be making the progress I would have liked to. There is some improvement, but i don't think my methyliation has kicked back into gear. I suspect I still have an issue somewhere in my folate metabolism, as well as in my transsulfuration, which I can't seem to get my head around. My SNP resuts are: COMT V158M (+/-) COMT H62H (+/-) VDR Taq (+/-) VDR Fok (+/-) MAO A R297R (+/+) MTHFR C677T (+/-) MTHFR 1298C (+/-) MTRR A66G (+/-) MTRR 11 (+/-) BHMT 1 (+/-) BHMT 8 (+/-) AHCY 1,2,19 (+/-) CBS699T (+/-) CBS A360A (+/+) SHMT C1420T (+/-) NOS D298R (+/-) All other are (-/-), including the SUOX S370S. I do have adrenal fatigue and some blood sugar issues, which I guess is in line with the above SNPs. Not sure if my G6D... Enzyme is also faulty, as this was not tested. My customised multivitamin includes 400mg chromium and 200mg vanadium for that purpose. I also use cinnamon in foods as often as possible and went for a LOGI diet, which should take care of the issue. My fasting glucose level went down from 95 to 85, which indicates I am on the right path, so that can't be a problem. Glutathione was low, but has been brought up with glutathione IVs, which helped my functioning GST enzyme system kick into gear. Not a long term solution, I know, so now I still have to figure out how to get the methyliation going properly. I believ my probblem is either in the B12/Folate or the transulfuration. I do take 1 B-Complex from pure encapsulations a day, which gives me 400mcg of Methylcolbalamin and 400mcg of 5MTHF per day. I addition, I take a 1000mcg injection in an iv drip per week. Based on my genetics, I understand that I don't need that much B12. Urine MMA is also not detectable, which indicates I should be fine there. Urine FIGLU is also great, so I should not have any folate issue, but I am not sure on that. All alternative medicine testings I have done so far, indicate I need folic acid (!). Maybe just 5MTHF is not enough and I need a second form? What is also puzzeling to me, is my constellation of CBS upregulation, together with my SUOX (-/-). The Yasko test indicates that for the SUOX, no support is needed, and that field is green coloured, while now I have read, that "normal" suox is (+/+)!!! The Metamatrix test results showed typical CBS upregulation (high taurine, high alpha keto glutarate, low BH4, etc, etc). So I am refraining from taking sulfates at the momennt. However, now I understand that my SUOXX enzyme might impair the conversion of Cystein to Sulfate, which means I might need sulfates? Maybe this is impairing my own formation of glutathione? My moly was low, so I am supplementing with 500mcg daily. Copper is at 3mg, as thsi was low as well. Zinc 30mg (I have HPU), B6 only 12.5 mg active/12.5mg inactive, just what is in the B-Complex. I take additional active B2 (36.5mg), 5mg Biotin for blood sugar and NADH. Fumarate was low, so I take around 900mg carnitine fumarate a day. That fits well to the high lactate which was found and my apparent problem with carbohydrate metabolism. I take 100mg of CQ10 (Ubiquinol) a day, Vitamin D, Super K tablet. Since my BH4 levels were low, I have now started on low dose of Kuvan, at 2mg per day. I had some dizziness the first few days, but that was it. However, I seem to have developped some insomnia. New blood results indicated that I have now replenished my deficient minerals and am now on a high level, which means I might want to cut down a bit. My underlying problem is lyme, which was coupled with a gigantic tapeworm that made me loose an incredible amount of weight in a short space of time and which apparently I have fostered nicely with high doses of high quality supplements. I took doctors just 10 months to find it.... If anybody might have an idea what might be holding back the proper functioning of the methyliation cycle or how to supplement the combination of the CBS upregulation with my SUOX enzyme,, pls let me know. I intend to run another metamatrix panel in around 1-2 months time, once I have finished my current round of antibiotics. Thanks!