Choline on the Brain? A Guide to Choline in Chronic Fatigue Syndrome
http://phoenixrising.me/research-2/the-brain-in-chronic-fatigue-syndrome-mecfs/choline-on-the-brain-a-guide-to-choline-in-chronic-fatigue-syndrome-by-cort-johnson-aug-2005
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(Video) OMF Scientific Advisory Board Member Mark Davis, PhD, Presents An Update on ME/CFS Research

Discussion in 'Latest ME/CFS Research' started by Ben H, Jun 6, 2018.

  1. Ben H

    Ben H OMF Correspondent

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    [​IMG]
    OMF Scientific Advisory Board Member Mark Davis, PhD, Presents
    An Update on ME/CFS Research

    Dear all,

    We are pleased to share a new research update by OMF's Scientific Advisory Board member, Mark M. Davis, PhD, produced by Ashley Haugen for this #OMFScienceWednesday.
    Dr. Mark Davis, Director of the Stanford Institute for Immunity, Transplantation, and Infection, talks about his work with T-cells to understand their role in ME/CFS and to determine if ME/CFS is an autoimmune disease. Watch the video here.



    To support this important research, please donate now.

    With hope for all,

    [​IMG]
    Linda Tannenbaum
    CEO/President

    [​IMG]
    www.omf.ngo

    @Janet Dafoe (Rose49) @AshleyHalcyoneH @marilynbsg
     
    Sing, sb4, Mel9 and 22 others like this.
  2. Ben H

    Ben H OMF Correspondent

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    Just watched the video myself...what a cool dude Mark is. Sounds very exciting..I’d like to see what these candidates are. Love the respect shown towards the whole team, Mark is a mega name in his field.

    Big thanks to Ashley for her hard work making the videos and all the editing. She works so hard for the cause.


    B
     
  3. ScottTriGuy

    ScottTriGuy Stop the harm. Start the research and treatment.

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    As much I appreciate and support the work of the OMF, it just makes me cringe when he used the term 'chronic fatigue' 3 times in the first 1:40.

    Surely he is aware of how the conflation of 'chronic fatigue' and 'chronic fatigue syndrome' (and with the later, the term itself) have, and continue to undermine our collective efforts.

    Sigh.
     
  4. Hubris

    Hubris

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    I think he and Ron are doing that precisely for this reason, to avoid patients being discriminated because their doctor tells them "you have chronic fatigue not me/cfs so it's psychosomatic". Maybe i'm wrong but it would make sense.
     
    alkt likes this.
  5. Diwi9

    Diwi9 Senior Member

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    It would be interesting to hear how T-cell clonal expansion and the metabolic trap hypothesis might tie into one another. I have many markers for an increased risk of auto-immune diseases and have family members with them (MS, ulcerative colitis, Hashimoto's)...is anyone aware of survey/study data showing that PwME tend to come from families with histories of auto-immunity?
     
  6. bertiedog

    bertiedog Senior Member

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    I wonder how it fits with the role of the gut causing illnesses because of immune activation.

    Pam
     
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  7. AdamS

    AdamS Senior Member

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    Love this guy! So glad/grateful that we have him helping us!
     
  8. Vicki Cole

    Vicki Cole Senior Member

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    I am so appreciative of all of this research - it is truely amazing; but I didn't hear anything different to what was said at the symposium last year? Please correct me if I am wrong...
     
    Aroa and alkt like this.
  9. Frenchguy

    Frenchguy Senior Member

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    I think that the "impaired enzyme" mentionned for the metabolic trap hypothesis can have a great effect on the regulatory part of the immune system.
     
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  10. neweimear

    neweimear Senior Member

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    Oh God, me too. I can't take 'chronic fatigue'. So grateful for all the work but please use ME/CFS.
     
  11. neweimear

    neweimear Senior Member

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    I thought the same, they are still obviously searching but no answers just yet. We just have to hope that it's sooner rather than later.
     
    Vicki Cole likes this.
  12. ljimbo423

    ljimbo423 Senior Member

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    Hi Pam- This study shows that lipopolysaccharides (LPS) from gram negative bacteria, many of which, live in the gut as a part of the normal microbiome.

    Activate CD8+ T cells, which would lead to there cloning. Which is what Mark Davis is talking about in the video.

    If someone had increased intestinal permeability, than that would increase the level of LPS in the blood, causing immune activation. Part of that immune activation could be CD8+ T cells.

    Direct recognition of LPS by human but not murine CD8+ T cells via TLR4 complex.

    LINK

    Here is a study that shows LPS activate CD8+ T cells in rheumatoid arthritis.


    Jim
     
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  13. Sushi

    Sushi Moderation Resource Albuquerque

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    I really want to second that and let @AshleyHalcyoneH how much we appreciate these videos. She also has the sensitivity to edit them into a short enough version that most of us can take them in!
    Maybe that could be a video topic that Ron could take up? @Janet Dafoe (Rose49)
    Anecdotally, we hear this a lot. Maybe we could start a poll though statistically our polls are not very accurate--still it would be interesting.
     
    bertiedog, Diwi9, Murph and 1 other person like this.
  14. jpcv

    jpcv Senior Member

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    I think Davis`work,along with the data from Naviaux and others who are studying metabolome, are the most important in the research of ME/CFS
     
    Jackb23 likes this.
  15. Janet Dafoe (Rose49)

    Janet Dafoe (Rose49) Board Member

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    We now have one of Mark's post-docs working on this, I think full time. And the funding to do it. I know the post-doc has presented at one of their weekly meetings, and everyone thought he was great. I don't know what he has done past what Mark talked about, but I know that he has been doing things. Sorry for not much info, but it is progress to have a whole new person and the funding for the project to move forward. Funding is always the rate limiting step so far.
     
  16. Vicki Cole

    Vicki Cole Senior Member

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    I wonder why Mark isn't working on it himself?
    Thanks for feeding back - I felt a little disheartened seeing the video in that nothing seemed to have been done in nearly a year...

    Could the clonal t cells be something to do with gut bacteria permiating the gut wall (or a specific bacteria/virus) and the immune system battling it constantly... I ask because I have symptoms worsen when my gut symptoms are bad.
     
    ljimbo423 and adambeyoncelowe like this.
  17. Cam Newton

    Cam Newton

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    I was a grad student before I got ME/CFS. From my experience professors typically are more like managers who oversee the research of their lab. Most research is done by grad students and post docs. The profs usually oversee their work, give them ideas, write proposals for funding, teach classes, do peer review of journals, look over admissions, etc.
     
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  18. jpcv

    jpcv Senior Member

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    Or the other way around?
    For me, my gut worsens when I have a crash
     
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  19. Vicki Cole

    Vicki Cole Senior Member

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    That's what I meant. My gut is bad when my symptoms are bad. A direct correlation.
     
    ljimbo423 likes this.
  20. raghav

    raghav Senior Member

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    Is the t-cell sequence in the clonal expansion the same in all the patients or is it a different seqeunce in different patients ?
     

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