In the last week, I seem to have developed tingling and prickling sensations. These occur mostly in my legs, with occasional stabbing pains in my thighs and on the top of my foot. I'd had brief,random episodes of this once or twice before in the past few months but it always passed quickly. The prickling is usually also accompanied by anxiety and sweating feet and nausea. I've also noticed more muscle weakness especially in my legs. I have a whole list of possibilities and am wondering if Valcyte neuropathy comes on suddenly like this? I've been taking 1800 mg for just over a year. I dropped down to 1350 last week, then 900 and then stopped it yesterday totally. If it is the Valcyte, I wonder how long it will take to improve? I wasn't really ready to stop it yet but the prickling and anxiety is just awful. I also think it could be related to low estrogen, starting high dose hydroxyb12, or possibly even a lyme herx from roxithromycin. I've stopped all these too (except the estrogen). Too many variables and I'm flummoxed. I already take most of the supplements too that are meant to help with neuropathy. Mostly I just really need this to go away because it is freaking me out! Any thoughts? Does this sound like Valcyte neuropathy or is there no way to know but to wait and see if it gets better?