Treatment implications of the Naviaux study (PNAS, August 2016)

[seunderwood]

Just a thought, Why not improve the butyrate deficiency noted by Dr Lipkin , and let the B vitamins synthesise themselves in the gut ??

 

[hixxy]

Just a thought, Why not improve the butyrate deficiency noted by Dr Lipkin , and let the B vitamins synthesise themselves in the gut ??

Because we don't have "normal" b vitamin deficiencies, we have functional deficiencies as a result of low NADPH.

 

[GodGenghis]

I'm curious about the Suramin treatment for Autism trial results. Anyone heard when these might be published? I guess given it only completed in April there could be a fairly long wait yet.

@hixxy I read somewhere just the other day that the expectation is that this suramin autism study will be published before the end of the year. I wish I could provide a citation for you.

 

[keenly]

So, it's finally out!

http://www.pnas.org/content/early/2016/08/24/1607571113.long

It's way over my head. Are there any treatment implications? Any tests we should be getting? Are there doctors who would know what to do with the info?

P. 7:

Cheney may have been right about uric acid all along.

 

[Never Give Up]

Just read elsewhere that Dr. Naviaux' Suramin autism study will be published on 5/26/17 and that he plans to do a Suramin trial on ME/CFS patients next. I have no other information, perhaps he'll talk about it during his CDC chat on the 25th.

 

[Countrygirl]

https://en.wikipedia.org/wiki/Suramin

The most frequent adverse reactions are nausea, vomiting, diarrhea, abdominal pain, and a feeling of general discomfort. It is also common to experience various sensations in the skin, from crawling or tingling sensations, tenderness of palms and the soles, and numbness of hands, arm, legs or feet.[11] Other skin reactions include skin rash, swelling and stinging sensation.[11] Suramin can also cause loss of appetite and irritability.[11]Suramin causes non-harmful changes in urine during use, specifically making the urine cloudy.[11]

Less common side effects include extreme fatigue, ulcers in the mouth, and painful tender glands in the neck, armpits and groin.[11] Suramin uncommonly affects the eyes causing watery eyes, swelling around the eyes, photophobia, and changes or loss of vision.[11]

Rare side effects include hypersensitivity reactions causing difficulty breathing. Other rare systemic effects include decreased blood pressure, fever, rapid heart rate, and convulsions.[11] Other rare side effects include symptoms of liver dysfunction such as tenderness in upper abdomen, jaundice in eyes and skin, unusual bleeding or bruising.[11]

Suramin has been applied clinically to HIV/AIDS patients resulting in a significant number of fatal occurrences and as a result the application of this molecule was abandoned for this condition.[12]

Deep joy!

Years ago I recall listening to Prof Malcolm Hooper lecture on the 'fact' ? that ME and autism are bio-chemically the same. I also have his book he wrote on the subject, although not having a PhD in bio chemistry my brain cell collapsed when reading it.

I might dig it out of my bookcase again..

 

[ScottTriGuy]

https://en.wikipedia.org/wiki/Suramin

Suramin has been applied clinically to HIV/AIDS patients resulting in a significant number of fatal occurrences

Yikes.

 

[perrier]

Suramin sounds frightening
After so much suffering a medication which could cause even more.....