The 12th Invest in ME Conference, Part 1
OverTheHills presents the first article in a series of three about the recent 12th Invest In ME international Conference (IIMEC12) in London.
Discuss the article on the Forums.

Transforming growth factor beta (TGF-β) in adolescent chronic fatigue syndrome

Discussion in 'Latest ME/CFS Research' started by hixxy, Dec 6, 2017.

  1. hixxy

    hixxy Senior Member

    Messages:
    1,166
    Likes:
    1,349
    Australia
    https://www.ncbi.nlm.nih.gov/pubmed/29202780
    https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-017-1350-1
     
  2. Gijs

    Gijs Senior Member

    Messages:
    652
    Likes:
    1,332
    So Montoya is wrong (?). TGF b must be replicated in adults too, but i think TGF B and cytokines are not usefull for markers in ME patiënts at all!
     
  3. Londinium

    Londinium Senior Member

    Messages:
    178
    Likes:
    1,420
    Given the selection criteria, I'm not sure there's much we can conclude from this study at all.
     
  4. Murph

    Murph :)

    Messages:
    791
    Likes:
    3,851
    I thought that when I started reading it, but they subgrouped for Canadian criteria and still came up empty.

    >Subgrouping according to the Fukuda and Canada 2003 criteria of CFS did not reveal differential results.
     
  5. Philipp

    Philipp

    Messages:
    80
    Likes:
    509
    Are plasma levels the most relevant thing to look at here? I vaguely remember Prof Edwards commenting that tgf-b is used to somehow mark cells for a longer period of time (if I understood correctly), so depending on how this stuff works (I have no clue obviously), maybe there are bouts of transiently high levels followed by a regression to the mean which would be difficult to capture unless it is known when to look as well as where? Or the plasma tgf-b is used up at roughly the same speed as it is produced so levels stay constant, but turnover may be higher if more cells are 'painted' with it?

    It is interesting anyway that cortisol & (nor-)epinephrine are mentioned in this context since those do come up time and again.
     

See more popular forum discussions.

Share This Page