Anyone heard or used this? It is approved in Russia for kids over 3 years of age.
It works by inhibiting S100B.
(interestingly S100B is increased in autism bloods and levels correlate with severity of symptoms "S100B is a calcium-binding protein that is produced primarily by astrocytes. Increased serum S100B protein levels reflect neurological damage... “). I don't think it has been looked at in CFS/ME but could be wrong ?
There is lots of info here if you speak Russian
http://www.tenoten-deti.ru/
Tenoten in the therapy of patients with moderate cognitive impairment.
Duma SA, Shishkin SV.
Bull Exp Biol Med. 2009 Aug;148(2):353-6.
http://pmid.us/20027370
Tenoten is a new anxiolytic and antidepressant based on antibodies to brain-specific protein S-100B. Experimental studies demonstrated the effect of tenoten on mechanisms of neuronal plasticity and manifestations of higher nervous activity. Tenoten is clinically comparable with amitryptiline, sertraline, and phenazepam, but does not produce potent sedative relaxation effect typical of these drugs. The study demonstrated considerable improvement of the control over brain frontal compartment effector functions. Tenoten is recommended not only at the stage of moderate cognitive impairment, but also in manifest cerebrovascular pathologies characterized by pronounced impairment of the regulatory functions of the frontal compartments of the brain.
Efficiency of antianxiety preparation tenoten used in complex therapy of patients with Helycobacter pylory-associated ulcer disease of the duodenum.
Tsukanov VV, Kupershtein EY, Sharypova VN.
Bull Exp Biol Med. 2009 Aug;148(2):351-2.
http://pmid.us/20027369
P01-219 - Clinical efficacy of tenoten for children in treatment of attention deficit and hyperactivity disorder
http://www.sciencedirect.com/science/article/pii/S0924933810704259
Nootropic and antiamnestic effects of tenoten (pediatric formulation) in immature rat pups.
Voronina TA, Molodavkin GM, Borodavkina MV, Kheyfets IA, Dugina YL, Sergeeva SA. Bull Exp Biol Med. 2009 Sep;148(3):524-6. English, Russian.
http://pmid.us/20396730
The use of tenoten preparation in complex therapy of hypomotoric biliary dyskinesia.
Simanenkov VI, Poroshina EG, Tikhonov SV.
Bull Exp Biol Med. 2009 Aug;148(2):349-50.
http://pmid.us/20027368
Clinical effects of anxiolytic preparation tenoten in complex therapy of essential hypertension.
Nikol'skaya IN, Guseva IA, Bliznevskaya EV, Tret'yakova TV.
Bull Exp Biol Med. 2009 Aug;148(2):346-8.
http://pmid.us/20027367
Tenoten in the therapy of anxious disturbances in patients with essential hypertension and coronary heart disease.
Vanchakova NP, Popov AP.
Bull Exp Biol Med. 2009 Aug;148(2):343-5.
http://pmid.us/20027366
The use of tenoten and tenoten (pediatric formulation) as a drug for premedication in adults and children during outpatients dentist visit.
Larentsova LI, Lyubimova DV, Fokina TY, Rvacheva EA, Sosul'nikov DV.
Bull Exp Biol Med. 2009 Aug;148(2):340-2.
http://pmid.us/20027365
The use of tenoten (pediatric formulation) in the therapy of chronic tension-type headaches in children.
Barkhatov MV, Barkhatova SY, Nosyrev AV, Zorin NA, Borodavkina MV, Kheifets IA, Kachanova MV, Sabanov LV.
Bull Exp Biol Med. 2009 Aug;148(2):337-9.
http://pmid.us/20027364
Psychotropic drug tenoten activates mitogen-activated MAP/ERK kinase regulatory cascade controlling the neuroprotective effects.
Epstein OI, Vorobieva OV, Grinkevich LN, Kharchenko OA, Shtark MB.
Bull Exp Biol Med. 2007 Sep;144(3):319-21.
http://pmid.us/18457026
http://www.pharmoutlet.com/buy/Tenoten-for-children-tablets-No40
It works by inhibiting S100B.
(interestingly S100B is increased in autism bloods and levels correlate with severity of symptoms "S100B is a calcium-binding protein that is produced primarily by astrocytes. Increased serum S100B protein levels reflect neurological damage... “). I don't think it has been looked at in CFS/ME but could be wrong ?
There is lots of info here if you speak Russian
http://www.tenoten-deti.ru/Tenoten in the therapy of patients with moderate cognitive impairment.
Duma SA, Shishkin SV.
Bull Exp Biol Med. 2009 Aug;148(2):353-6.
http://pmid.us/20027370
Tenoten is a new anxiolytic and antidepressant based on antibodies to brain-specific protein S-100B. Experimental studies demonstrated the effect of tenoten on mechanisms of neuronal plasticity and manifestations of higher nervous activity. Tenoten is clinically comparable with amitryptiline, sertraline, and phenazepam, but does not produce potent sedative relaxation effect typical of these drugs. The study demonstrated considerable improvement of the control over brain frontal compartment effector functions. Tenoten is recommended not only at the stage of moderate cognitive impairment, but also in manifest cerebrovascular pathologies characterized by pronounced impairment of the regulatory functions of the frontal compartments of the brain.
Efficiency of antianxiety preparation tenoten used in complex therapy of patients with Helycobacter pylory-associated ulcer disease of the duodenum.
Tsukanov VV, Kupershtein EY, Sharypova VN.
Bull Exp Biol Med. 2009 Aug;148(2):351-2.
http://pmid.us/20027369
P01-219 - Clinical efficacy of tenoten for children in treatment of attention deficit and hyperactivity disorder
http://www.sciencedirect.com/science/article/pii/S0924933810704259
Nootropic and antiamnestic effects of tenoten (pediatric formulation) in immature rat pups.
Voronina TA, Molodavkin GM, Borodavkina MV, Kheyfets IA, Dugina YL, Sergeeva SA. Bull Exp Biol Med. 2009 Sep;148(3):524-6. English, Russian.
http://pmid.us/20396730
The use of tenoten preparation in complex therapy of hypomotoric biliary dyskinesia.
Simanenkov VI, Poroshina EG, Tikhonov SV.
Bull Exp Biol Med. 2009 Aug;148(2):349-50.
http://pmid.us/20027368
Clinical effects of anxiolytic preparation tenoten in complex therapy of essential hypertension.
Nikol'skaya IN, Guseva IA, Bliznevskaya EV, Tret'yakova TV.
Bull Exp Biol Med. 2009 Aug;148(2):346-8.
http://pmid.us/20027367
Tenoten in the therapy of anxious disturbances in patients with essential hypertension and coronary heart disease.
Vanchakova NP, Popov AP.
Bull Exp Biol Med. 2009 Aug;148(2):343-5.
http://pmid.us/20027366
The use of tenoten and tenoten (pediatric formulation) as a drug for premedication in adults and children during outpatients dentist visit.
Larentsova LI, Lyubimova DV, Fokina TY, Rvacheva EA, Sosul'nikov DV.
Bull Exp Biol Med. 2009 Aug;148(2):340-2.
http://pmid.us/20027365
The use of tenoten (pediatric formulation) in the therapy of chronic tension-type headaches in children.
Barkhatov MV, Barkhatova SY, Nosyrev AV, Zorin NA, Borodavkina MV, Kheifets IA, Kachanova MV, Sabanov LV.
Bull Exp Biol Med. 2009 Aug;148(2):337-9.
http://pmid.us/20027364
Psychotropic drug tenoten activates mitogen-activated MAP/ERK kinase regulatory cascade controlling the neuroprotective effects.
Epstein OI, Vorobieva OV, Grinkevich LN, Kharchenko OA, Shtark MB.
Bull Exp Biol Med. 2007 Sep;144(3):319-21.
http://pmid.us/18457026
http://www.pharmoutlet.com/buy/Tenoten-for-children-tablets-No40