International ME/CFS and FM Awareness Day Is On May 12, 2018
Thomas Hennessy, Jr., selected May 12th to be our international awareness day back in 1992. He knew that May 12th had also been the birthday of Florence Nightingale. She was the English army nurse who helped to found the Red Cross as well as the first school of nursing in the world.
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Study finds form of actin determined by non-coding DNA

Discussion in 'Other Health News and Research' started by anciendaze, Jan 3, 2018.

  1. anciendaze

    anciendaze Senior Member

    This finding just about knocked me over. It took place at a school of veterinary medicine, so will likely be ignored by human medical researchers until replicated in humans.

    Beta and gamma actin are very important in cell biology, and behave differently. These researchers claim the tiny differences in observed amino acid differences are not the reason for the differences in shape of these proteins. If they are right it seems the nucleic acid sequence going into the ribosome is the thing that controls the form of the protein that emerges. Non-coding DNA is transcribed to mRNA which actually controls the process without resulting in any amino acids in the sequence.

    One immediate consequence I see is that viral RNA could alter the process without changing host genes. Actin is vital for movement of cells other than muscles, like immune cells.

    Is this at all relevant to ME/CFS? Well, it could be. Recall that Baraniuk's study of miRNA in cerebrospinal fluid showed differences in CFS patients and GWI patients compared to sedentary controls in response to exercise.
    ScottTriGuy likes this.

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