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Spread of EBV to ectopic lymphoid aggregates may be the final common pathway in CFS pathogenesis

Discussion in 'Latest ME/CFS Research' started by MikeJackmin, Mar 4, 2017.

  1. MikeJackmin

    MikeJackmin Senior Member

    The spread of EBV to ectopic lymphoid aggregates may be the final common pathway in the pathogenesis of ME/CFS

    [​IMG]Email the author Willy Eriksen
    Domain for Mental and Physical Health, Norwegian Institute of Public Health, Box 4404 Nydalen, 0403 Oslo, Norway

    According to the hypothesis presented here, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) develops over 3 steps: Step 1 is characterized by the aggregation of lymphoid cells in dorsal root ganglia or other nervous structures. The cause of this formation of ectopic lymphoid aggregates may be an acute infection, asymptomatic reactivations of a common neurotropic virus, exposure to a neurotoxin, or physical injury to peripheral nerves. In step 2, Epstein-Barr virus (EBV)-infected lymphocytes or monocytes bring EBV from the circulation to one or several of these lymphoid aggregates, whereupon cell-to-cell transmission of EBV and proliferation of latently EBV-infected lymphocytes lead to the presence of many EBV-infected cells in the lymphoid aggregates. The EBV-infected cells in the aggregates ignite an inflammation in the surrounding nervous tissue. This local inflammation elicits, in turn, a wave of glial cell activation that spreads from the EBV-infected area to parts of the nervous system that are not EBV-infected, disturbing the neuron-glial interaction in both the peripheral - and central nervous system. In step 3, immune cell exhaustion contributes to a consolidation of the pathological processes. There might be a cure: Infusions of autologous EBV-specific T-lymphocytes can perhaps remove the EBV-infected cells from the nervous system.
  2. Rrrr

    Rrrr Senior Member

    But where does one get these autologous EBV-specific T-lymphocytes cells and how do you administer them? Is it like stem cells?
    oiseau likes this.
  3. ash0787

    ash0787 Senior Member

    I never had EBV though according to the doctors, I made them do a blood test within a month to try and detect it and they said it wasn't, it also didn't seem like EBV in terms of symptoms / duration.
    oiseau likes this.
  4. Snow Leopard

    Snow Leopard Hibernating

    South Australia
    Interesting hypothesis, but almost certainly wrong.

    As Ash0787 says, some of us haven't (or hadn't) been infected with EBV - I too tested negative on multiple tests (in different countries no less), straight after and years after becoming ill.
    oiseau and ash0787 like this.

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