(1) Severe symptoms experienced by patients with ME / CFS - characterized by great physical and mental fatigue that is not relieved by rest-along to -faringitis other symptoms or tonsillitis, tender lymph nodes, muscle pain, joint pain, headaches, sleep disturbance and discomfort that persists for more than twenty four hours after a work-requires a major effort to adapt to it.
(2) The sociodemographic and clinical circumstances, which can be subdivided into two. On the one hand those we regard as inevitable; ie those that arise because of being sick ME / CFS, such as the sudden limitations because of the disease in relation to the areas of "Leisure", "Unit" and "Environmental / Chemical". On the other Avoidable "that is, caused by behavioral interventions from outside the sick person, as are those of all intrusive and very deleterious Sanitary areas, psychological, labor, financial and social and family of daily life person.
(3) modulating variables, mainly those who have demonstrated a high power to reduce, significantly, the effects of sociodemographic circumstances and clinics, such as quality of life, sense of coherence and psychological wellbeing.
So if in a person suffering from ME / CFS converge the three independent macro-variables: the harsh characteristics of the disease characteristics, some demographic circumstances and clinics, which invade the most significant areas of the person, limiting and deteriorating severely the daily life of these patients, and deficient modulatory variables, then the chance of developing states of depression, hopelessness and suicide risk is multiplied at high levels (dependent variable).