It is a puzzling, yet quite common occurrence for CFS patients to experience brief periods of recovery when taking on new treatments. This is often accepted as a placebo effect by medical carers. I also have experienced brief episodes of recovery that have coincided with a new treatment, which I can't accept as being simply a placebo effect. If this has been discussed before please let me know, but if we exclude the placebo effect, what other possibilities are there. It is possible for the recovery period to be coincidental to the application of a treatment. Another possibility is that there is some self adjusting mechanism operating that resets our systems back to the poor level prior to taking the treatment. What sort of body system could do this? Could it be bacterial populations in our digestive system which do the resetting? Millions of mutant, self aware bugs plotting our downfall? I am considering this possibility because I am about to embark on a B12 methylation protocol and after reading some of the posts about faecal testing I have also decided to massively dose myself with probiotics. And let me say, I have not abandoned XMRV, I am just sick and tired of waiting around for something to happen. Any thoughts?