kaffiend
Senior Member
- Messages
- 167
- Location
- California
I was just researching the role of the 5HT-2C receptor in fatigue states and came across a drug, which is available in Europe and Australia, that might benefit those with sleep and neuroendocrine disturbances. The drug is called agomelatine. In addition to its activity at the 5HT-2C receptor, it is also a melatonin receptor agonist. Antagonism of the 5HT-2C receptor would have the effect of increasing dopamine and norepinephrine in the brain. There some evidence that the 5HT-2C receptor is UPregulated by cytokines, thereby reducing dopamine and norepinephrine and producing problems with mood, attention, alertness, etc.
Also, women receive two copies of the gene that codes for it while men receive only one.
Some more info here:
http://en.wikipedia.org/wiki/5-HT2C_receptor
http://en.wikipedia.org/wiki/Agomelatine
Also, women receive two copies of the gene that codes for it while men receive only one.
Some more info here:
http://en.wikipedia.org/wiki/5-HT2C_receptor
http://en.wikipedia.org/wiki/Agomelatine