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This is a great letter and I appreciate those who wrote and signed it.
Was it posted solely on the Virology blog or was it also sent to Dr. Horton and Lancet?
I don't know but I would imagine they've sent a copy - wouldn't be much point, otherwise.
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Its an Open Letter to Richard Horton, Editor of the Lancet, and The Lancet. Richard Horton can hardly ignore it.
"The case against science is straightforward: much of the
scientific literature, perhaps half, may simply be untrue.
Afflicted by studies with small sample sizes, tiny effects,
invalid exploratory analyses, and flagrant conflicts
of interest, together with an obsession for pursuing
fashionable trends of dubious importance, science has
taken a turn towards darkness. As one participant put
it, “poor methods get results”.
- Richard Horton
Well I would say that's Mornington Crescent isn't it?
At least it is something to relish.
This is excellent
However, it's worth noting that many of these key points have already been raised in previous correspondence relating to previous PACE trial papers.
Eg the letters to the editor that followed the first paper on 'recovery' following PACE trial interventions
http://www.meassociation.org.uk/.../pace-trial-letters.../
These criticisms were very firmly dismissed by the authors and by the Lancet.
So we are still on an uphill struggle...