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Science: A molecular link between exercise and weight loss

Discussion in 'Other Health News and Research' started by Firestormm, Jan 7, 2014.

  1. Firestormm

    Firestormm

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    As many of us can't exercise without exacerbating our symptoms, and some of us - like me - I suspect have gained weight especially after the initial few years of losing it - this article might be interesting:

    From Science January 7th 2014:

     
  2. lansbergen

    lansbergen Senior Member

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    What if you waist size drops without exersice? Lately mine has with at least 10cm. My abdominal wall has become more supple too.
     
  3. Firestormm

    Firestormm

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    In my first 5 years of ME diagnosis I suffered great weight loss. How far into it all are you Ian?

    I was speculating - in relation to the above - if because we can't exercise at all or very well if this molecule is perhaps not being released and used to help release energy in the same efficient manner as it might it we did/could exercise.
     
  4. lansbergen

    lansbergen Senior Member

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    I am not Ian. It started 28 years ago so my first years are long gone.
     
  5. Firestormm

    Firestormm

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    Apologies Iansbergen. A shrinkage in waist-size like you mention - over what period you don't say - would worry me. Obviously there can be many reasons for weight gain and loss, lack of exercise and diet being but two. When I did lose a lot of weight in those years, and failed to put it on, I had fairly continuous diarrhea but then I was also under fairly continuous stress - more so than before any diagnois of ME. So I don't know. Medications that I take now are apparently known to lead to weight-gain, but i tend to think that now - as I am eating and my diet is more normal - it's down to lack of exercise ability.
     
  6. lansbergen

    lansbergen Senior Member

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    I am not worried. I am convinced its one of many things that happen with improvement.

    I am not sure how long it is going on. Could be six months or a year. I noticed it because my trousers started to drop to my ankles.
     
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  7. Marco

    Marco Grrrrrrr!

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    Hi Russ

    PGC1a isn't just beneficial with respect to exercise capacity but protective against many chronic diseases involving chronic systemic inflammation including neuroinflammatory diseases (now thought to include Alzheimers, Parkinsons, Huntingtons, major depression etc)

    The role of exercise and PGC1α in inflammation and chronic disease

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587487/#!po=7.89474

    Some quotes :

    “Conversely, animals with PGC-1α specifically ablated from skeletal muscle exhibit a higher number of glycolytic muscle fibers and have a reduced endurance exercise capacity”

    “loss of PGC-1α specifically in muscle causes a transcriptional induction in muscle for many genes that can be part of local or systemic inflammation”

    “skeletal muscle PGC-1α levels correlate inversely with expression of IL-6 and TNFα in individuals with normal glucose tolerance and in type 2 diabetic patients”

    “The molecular mechanisms that link PGC-1α and inflammatory gene expression in muscle are unknown, but they may reflect the role of PGC-1α in the control of reactive oxygen species (ROS).”

    “many if not most chronic diseases of aging, including heart disease, cancer and neurodegeneration are associated with chronic inflammation. “

    etc ...

    It appears that PGC1a pathways are activated by 'moderate' endurance exercise of type I and type IIa mitochondria rich aerobic type muscle fibres rather than the fast twitch strength related and anaerobic/glycolytic type II fibres (some ME/CFS studies have shown a switch to the latter type IIb muscle fibres).

    Could this support a beneficial role for GET? (at least I've provided a scientific rationale for it – in theory).;)

    The above of course assumes that these protective pathways are properly activated in ME/CFS patients. If not - big problems. You would think it would be a promising area to look at.

    Other ways of stimulating PGC1a :

    Nicotine stimulates PGC1a as much as exercise (in rats and probably not recommended) :

    http://www.ncbi.nlm.nih.gov/pubmed/15525607

    Enhancing heat shock protein activity has the potential to induce the expression of mitochondrial regulating PGC1a. But several studies have shown attenuated HSP production in response to exercise in ME/CFS.

    One theory (yet to be tested) proposes that Doxycycline treatment may help improve the mitochondrial content of skeletal muscle in metabolic syndrome (White, 2010 – research proposal).

    I'm also pretty sure we've discussed PGC1a and how to activate several times before here including many compounds which are proposed to increase PGC1a activity.


    A little more discussion here – although you may wish to check the interpretation of the referenced material yourself :

    Health and Environmental Illness Research Blog

    http://heirsresearch.blogspot.fr/2010/01/neuroinflammation-and-diabetes-and-gsk.html
     
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  8. lansbergen

    lansbergen Senior Member

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    I said over and over again I need nicotine.
     
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  9. Firestormm

    Firestormm

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    @Marco thanks for all of that. Very interesting. I was only kicking around a theory on my own that it might apply to our state of health in some possible way. I didn't actually imagine that it might :)

    @lansbergen I used to smoke though not what I would call seriously. But I switched to e-cigarettes and vapourising. I do find, and I have no evidence of course, that the stimulant allows me to mentally function for longer and I suppose it must affect other things too. Though I'm not recommending it of course! :)
     
  10. Marco

    Marco Grrrrrrr!

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    Very heavy nicotine use in schizophrenics. It helps to control the delusional symptoms.

    Not that I'm suggesting any of us suffer from delusions of course :)
     
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  11. Firestormm

    Firestormm

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    @Marco No, no. I am very delusional :)
     
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  12. MeSci

    MeSci ME/CFS since 1995; activity level 6?

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    My weight has normalised without exercise too. Many of us have found that cutting out gluten and going low-carb will achieve this. Fat melted away effortlessly and muscle has built up. Like @lansbergen I have become flexible again after feeling like a rigid sack of potatoes for years, and it feels great at the age of 60 to have muscles that I can use again, albeit with the limited energy production imposed by ME.

    I lost a lot of weight in the early stages too, probably largely due to nausea, vomiting, diarrhoea and lack of appetite. Then it crept up, and at one point I was borderline obese, which horrified me.
     
  13. *GG*

    *GG* senior member

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    Luckily you have a few more options these days. Electronic cigaretter, gum or patches etc.

    GG
     
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  14. anne_likes_red

    anne_likes_red Senior Member

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    PGC-1α is strongly induced by cold exposure. I take ice baths (2 - 3 x week in summer more in winter when it's more practical) and it does feel like I'm getting the benefits of exercise! FWIW. :D
    Ice bathing has changed my body composition (more muscle, smaller waist) but weight's stayed stable.

    PGC-1α has specialised actions in different tissues.

    From here http://themedicalbiochemistrypage.org/pgc1.php ...after Brain:
    HD = Huntington's Disease

    Anne.
     
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  15. Marco

    Marco Grrrrrrr!

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    Just thought I'd add some more info just for the record while its still fresh :

    From wikipedia :

    PGC1a

    http://en.wikipedia.org/wiki/PPARGC1A

    With respect to the effects of aging on skeletal and heart muscle.

    A long detailed read but worth it if you're really interested :

    http://onlinelibrary.wiley.com/doi/10.1002/iub.608/pdf
     

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