I happen to be married to one of the subjects included in the Fluge/Mella study which is now initiated (Phase 3). I believe their work will be groundbreaking both in terms of possible treatment options and the understanding of mechanisms underlaying the condition. I think it is only a matter of time before ME is properly understood and also treatable. We actually live in the very city, the city of Bergen, where these doctors began their work. What would be the odds... They explore further the possibility of endotel dysfunction as a diagnostic tool, they explore gastric malfunctions, register activity levels (subjects are wearing a device that saves all information related to activity level during a week), they explore family genetics etc. And, from what I gather, Rituximab is not the only medication being considered, thus possibly enabeling a wider range of treatmant options in the future for those that do not benefit from having Rituximab infusions: It may just be a matter of finding the right medication, which is not uncommon for other autoimmune diseases.