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Results pretty good (?) apart from missing GSTT1 and red flag on CBS A360A

Discussion in 'Genetic Testing and SNPs' started by ukxmrv, Apr 15, 2014.

  1. ukxmrv

    ukxmrv Senior Member

    I finally got around to running my 23andme results through Genetic Genie etc and the only red flags that came up were

    GSTT1 Absent

    CBS A360A rs1801181 AA

    There were a few yellow flags and missing things as well but compared to others here I feel as if I may have got away lightly.

    SHMT1 C1420T rs1979277 AG
    BHMT-08 rs651852 CT
    MTRR A664A rs1802059 AG
    MTRR A66G rs1801394 AG
    COMT V158M rs4680 AG
    COMT H62H rs4633 CT
    VDR Bsm rs1544410 CT
    VDR Taq rs731236 AG
    MAO-A R297R rs6323 GT
    ACAT1-02 rs3741049 AG
    MTHFR C677T rs1801133 AG

    and yellows /missing from detox profile

    CYP1B1 R48G rs10012 -- no call
    CYP2C9*2 C430T rs1799853 CT
    CYP2C19*17 rs12248560 CT
    CYP2D6 S486T rs1135840 CG
    CYP2D6 2850C>T rs16947 AG
    NAT2 R197Q rs1799930 AG

    This is anything here that leaps out at anyone? In the past I've tested for low blood folate and low red blood cell glutathione. The NHS prescribed their folic acid treatment that did help with neuropathic type pain and some neurological symptoms but seems to have resulted in an increased inability to tolerate sulfurous veges.

    Have tried injections of Cyan B12 in the past with no obvious improvement, various types of folate and supplements around the Meth cycle but not hit on the right combo that improves symptoms.

    Anything obvious here?
    Last edited: Apr 15, 2014
  2. Valentijn

    Valentijn Senior Member

    @ukxmrv - The CBS +/+ isn't one that can cause problems.

    But missing GSTT1 causes problems in detoxing certain substances.

    MTHFR C677T being heterozygous also means that enzyme activity is reduced to 65% of normal, which would explain your low folate results. Supplementing methylfolate (not folic acid) may be helpful, since the mutation results in less conversion of folic acid into methylfolate.
    ukxmrv and maryb like this.
  3. caledonia


    Cincinnati, OH, USA
    All those yellows (+/-) can add up and still make you sick depending on environmental exposures. In fact, all of my SNPs except for one detox SNP are yellows. I just have a whole lot of them.

    You're taking synthetic folate and B12. Those are not going to be effective for your SNPs. Methylfolate is preferred for MTHFR. For your MTRRs (B12 recycling) you would need B12. Your COMT/VDR taq combo determines the type of B12. For you, Yasko suggests hydroxycobalamin and adenosylcobalamin. Taking methylcobalamin could cause an overdose of methyl groups, and thus mood swings. So it would be best to avoid that. B12 needs to be taken either sublingually or by injection, as it doesn't absorb well in the stomach.

    Read these two documents in my signature links for more info - Roadblocks to Successful Methylation and Start Low And Go Slow.
    helen1, ukxmrv and maryb like this.

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