Researchers Investigate Drug for Sepsis and SIRS

Drug may quell deadly immune response when trauma spills the contents of our cells' powerhouses


"The entire hypothesis behind this -- and it's called the danger theory -- is that our mitochondria used to be bacteria so when their contents are released our body treats them like an infection," Martinez Quinones says.



Deformylase improved sepsis survival in their animal model by 28 percent and prevented separation of the tightly knit human endothelial cells that keep blood vessel content contained.


They found that a routine flushing of the area significantly reduced levels of N-formyl peptides. They hypothesized then and are now studying whether more frequent flushing can help those patients keep levels low and reduce their risk of SIRS and sepsis.

https://www.sciencedaily.com/releases/2018/06/180611133810.htm