Hi, I am relatively new to this forum. I've had B12 deficiency before and was treated with injections; recently the tingling has returned, so I thought it might be coming back. I also recently got a 23andme test, and before this my doctor had told me I'm probably a poor methylator given that I eat well--lo and behold, I looked up my raw data and found I'm +/+ for MTHFR A1298C. Since then I've done a little research but am struggling to understand the correct supplement protocol. Genetic Genie also says I have these heterozygous mutations: VDR Bsm VDR Taq MTR A2756G MTRR A66G CBS C699T After reading into the possible symptoms, I'm wondering if these mutations are at least partly responsible for symptoms: lately, due to life circumstances, I've felt utterly depressed for about a year now and have little hope. I also have orthostatic hypotension, which seems to have been getting worse (I probably black out, without passing out, about 5-10 times per day when I stand up too quickly). What supplements would you recommend? Initially I thought methyl B12 and L-methylfolate, but after reading the SNP interpretation guide and Dr. Amy's Simplified Road Map, it seems like I should be taking all three types with less methyl B12? Thanks everyone--I appreciate all responses!