The (in)famous Coimbra protocol with mega doses of vitamin D. He claims the cure/remission rate is 95% for neuro and 100% for other autoimmune diseases.
I tried it for a year, (the dose was up to 120,000 IU per day), at first I felt extremely better (typical steroids effect??), but I think it made me more vulnerable to viruses, which caused problems. I got even worse since I quit it.
If the dose wasn't so high maybe would end up better.
Also I suspect that in fact it made me better 'only' because vit D is also mast cells stabilizer, and anti-inflammatory, it definitely didnt address the cause of my disease because it would not make me worse in the end.
I have been following /and met personally/ many people who did this high dose protocol, most of them have MS, but some had other diseases too, and the claims of so high success are absolutely not supported.
It works for maybe 30% of pwMS (given the nature of that disease is also often relapsing-remitting it's hard to tell and even 30% could be overestimation)
Recently some girl on FB group mentioned she has MS and ME, and her ME is not good on protocol, while MS is good .(she's on high doses for 5 yrs). I was wondering if protocol actually is making her ME worse.
TLDR: high dose vit D is quackery