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Prof. Ron Davis: A glimpse into his London IIME18 talk :)

Discussion in 'Latest ME/CFS Research' started by Ben H, Jun 1, 2018.

  1. Ben H

    Ben H OMF Correspondent

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    [​IMG]
    A Glimpse into My London Talk

    Dear Friends,

    I prepared this statement for Ashley Haugen to read yesterday at the Western Massachusetts Department of Public Health screening of Unrest. This is new information from the Severely ill Patient Study (SIPS) that I also presented in London:

    We have made considerable progress in analyzing the data from the severely ill patient study. This has taken some time because we have only had one bioinformatic scientist analyzing the massive amount of data.

    We have found that there are a considerable number of mutations that are more common in ME/CFS patients than in healthy controls. This would suggest that these mutations make a patient more susceptible to having ME/CFS. It could also indicate that some of the mutations are responsible for the severity of the patients we studied. We also see a large number of metabolomic changes that have been previously seen in less severe patients.

    These metabolomic differences between healthy controls and our severely ill patients are often much bigger than in studies with less severe patients. A more detailed analysis of this data may aid us in developing treatments.

    One area we are currently studying using the genetic and metabolomic data is the possibility there may be one or more metabolic traps. This is a metabolic state that a patient can develop, possibly caused by physical stress such as infection. Once a patient is in this state they cannot easily get out by rest.

    We are conducting system biology and pathway analysis that shows that a metabolic trap is possible, and that some of the observed mutations make it more likely. If this is the case we should be able to push the patients out of this state by a specific metabolic intervention. We are very hopeful that this could be a one time treatment, take only a few days, and be relative inexpensive.

    Sending greetings from London,
    [​IMG]
    Ronald W. Davis, PhD
    Director, OMF ME/CFS Scientific Advisory Board
    Director, Stanford Genome Technology Center

    [​IMG]
    www.omf.ngo

    @Janet Dafoe (Rose49) @AshleyHalcyoneH
     
    Last edited: Jun 1, 2018
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  2. bertiedog

    bertiedog Senior Member

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    It does sound like Ron and his team are making good progress on our behalf. I for one would like to say a huge
    T H A N K Y O U.

    Pam
     
    lemonworld, Starlight, Mel9 and 12 others like this.
  3. Diwi9

    Diwi9 Administrator

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    Reading Ron's words is like receiving the best hug ever.
     
    Moof, Jackb23, bctjr1993 and 16 others like this.
  4. Mary

    Mary Moderator

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    I know this is a big if, but we can dream, can't we? :nerd: (what other medical researchers are concerned about making a life-changing therapy inexpensive?)
     
    sb4, Mel9, Laurie P and 6 others like this.
  5. lafarfelue

    lafarfelue Senior Member

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    Thanks for the update!

    Trying to keep my hope about the metabolic trap in check, but I'm also really interested to learn more about the common mutations that appear to relate to propensity toward ME/CFS.
     
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  6. Tally

    Tally Senior Member

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    Me too.

    I was a fetus when Chernobyl happened, but was in the area that received low dose radiation. I still wonder if that could have caused some of the mutations, or if they're herediatary.

    Too bad medical community completely failed to track ME/CFS and all we have are wild estimates of ME/CFS prevalence.
     
    wastwater likes this.
  7. perrier

    perrier Senior Member

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    Where were you conceived, in Belarus, or in Ukraine?
     
  8. Tally

    Tally Senior Member

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    Neither. Belarus and Ukraine has much higher levels of radiation than the rest of Europe. My country only got low dose. But birth defects were present all the way to UK.
     
    wastwater likes this.
  9. wastwater

    wastwater Senior Member

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    Radiation seems an obvious candidate could it better explain cluster outbreaks as well by creating an immunodeficiency
    My grandparents were possibly around nuclear testing maybe this affected genes

    GWS is another radiation candidate maybe reactions to vaccines were due to radiation effecting genes rather than vaccines being faulty
     
    Last edited: Dec 18, 2018

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