Jonathan Edwards
"Gibberish"
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I am afraid that I think you can construct a story linking just about anything with just about anything in those sorts of terms Hip. Building biological mechanisms for diseases in real life does not work on the basis of what fits with what. Everything fits with everything if you trawl through the literature. Building a useful model is much more to do with trawling through for what DOES NOT fit for a given theory. And often that has to do with broader system dynamics issues, or with quirky details shown up by exceptions to rules. If there was any specific conclusion about mechanism from the IiME workshop I think it was probably that we may be looking for a mechanism that leaves IL-6 well alone. Sickness behaviour is a buzz word that does not quite fit here I think.