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Please Help me with MTHFR and 23andMe results

Discussion in 'General ME/CFS Discussion' started by KokoP, Jun 3, 2015.

  1. KokoP


    I'm desperate for some guidance with understanding my results from the 23andMe genetic test. Some of my SNP results are:

    rs1801133, versions are A or G, I am: AG
    -if I understand this correctly, I am heterozygous for this mutation

    rs1801131, versions are G or T, I am: TT
    -if I understand correctly, I am negative for caring a mutation with this gene

    rs2274976, versions are C or T, I am: CC
    -I don't know what this means

    And I don't know what else to really look for. I did the report, but am struggling to understand that too.

    I'm overwhelmed and really suffering. Please help if you can.
  2. Valentijn

    Valentijn Senior Member

    @KokoP - Based on those results, your MTHFR is functioning at about 65% of the optimal level. But average functioning in the general population is at about 70%, so that puts your MTHFR in the "extremely normal" range.

    It's unlikely to be causing significant problems. A low/normal dose of methylfolate might be helpful, especially if getting pregnant. Though eating a good amount of veggies will also fully compensate for the reduction.
    Eeyore and PeterPositive like this.
  3. Eeyore

    Eeyore Senior Member

    I would agree with @Valentijn - however, I'd add that rather than just going off genetics, get your homocysteine tested, and treat that down to normal range - with folate/b12/b6/tmg if necessary. If your homocysteine is normal I wouldn't worry about it.
    Gondwanaland likes this.
  4. MTHFR C677T +/-
    MTHFR A1298C -/-
    MTHFR G1793A (R594Q) -/-

    There are several ways to name the genes. It's easier to go with the letter/number combinations than the RS numbers in my opinion.

    You have the same results as me. MTHFR C677T is the most significant, resulting in a 40% or so reduction in the ability to convert folate into methylfolate. So you may need some methylfolate supplementation.

    But that's just one small piece of the puzzle. Do lots of research before implementing any supplements or treatments.

    See the link in my signature for a lot more info on interpreting SNPs. (Hint: you're doing it the hard way.)

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