Discussion in 'General ME/CFS Discussion' started by LizO, Jan 23, 2016.
I am posting this on behalf of my son:
Welcome tot the the forums.
Liver enzymes can be elevated for many reasons and the herbals/supplements intake can be one of them. Viral involvement like EBV can be another reason, and it has been my case early on in my disease.
Sending best wishes!
My ALT is high too. I was worried about liver damage so looked it up. It appears that high ALT is often associated with alcohol damage (oh dear!). However my AST/ALT is less than 1, which indicates non-alcohol damage.
It seems that these liver changes are likely caused by Lyme disease (which I have). From my reading of papers by Horowitz (2003) and Soloski (2014) Lyme disease causes increased markers for liver damage. The damage caused either directly by bacterial liver infection, or by systemic cytokine release. The most common markers increased are GGT and ALT.
Thanks for your reply. His GP thought it might be something he was taking, so he stopped everything for 6 months and it was at the end of that period that he had the spike in ALT. EBV didn't seem to play a significant role in his aetiology. We will keep this in mind though!
We've come across a few papers suggesting Lyme can cause high ALT. However it doesn't seem likely that it is caused by Lyme, as Lyme does not cause foamy urine. The ALT seems to be directly attached to the foamy urine. which his NHS CFS/ME immunologist thinks we really need to get to the bottom of in particular. We are wondering if it might be a similar, undocumented bacterial infection - maybe in the blood or localised somewhere (gut? liver? sinuses? CNS?). He needs to get to hospital for further testing, but he is too ill.
Hi, LizO - any updates? If the foamy urine began after herbal antimicrobials, perhaps the release of lipopolysaccharide induced inflammation. I hope you've been able to find a cause by now.
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