JaimeS
Senior Member
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- 3,408
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- Silicon Valley, CA
Abstract:
Fatigue induced by complex dysfunctions of the central nervous system is frequently complained
by patients with cardiovascular risk factors. Although leptin is considered to regulate the central
nervous system, there are no reports regarding its association with fatigue in those patients. This
cross-sectional study included 347 patients with cardiovascular risk factors. Fatigue score and
plasma leptin concentration were measured. In addition, abdominal fat accumulation, systemic
inflammation, sleep condition, and functions of hypothalamus-pituitary axis and autonomic
system were estimated. Plasma leptin concentration (natural logarithm transformed) was
significantly and positively (r=0.222, p<0.001) associated with fatigue score, and significantly
(p<0.001) higher in the moderately-fatigued group (2.32±0.75 ng/ml, mean ± SD, n=52) than in
the normally-fatigued group (1.85±1.02 ng/ml, mean ± SD, n=295). Multiple logistic regression
analysis showed that plasma leptin concentration was significantly and independently associated
with a moderately-fatigued condition independent of other factors, including age, gender,
presence of diabetes, hypertension, dyslipidemia, alcohol consumption habit, urinary free cortisol,
serum high-sensitive CRP concentration, visceral and subcutaneous fat area, apnea/hypopnea
index, sleep efficiency, and heart rate variability. Hyperleptinemia may contribute to fatigue
severity in patients with cardiovascular risk factors.
http://www.psyneuen-journal.com/article/S0306-4530(16)30576-5/fulltext
Thought this was interesting. They do talk about chronic fatigue syndrome in the full text, and we've talked about leptin quite a bit on these boards...
-J
Fatigue induced by complex dysfunctions of the central nervous system is frequently complained
by patients with cardiovascular risk factors. Although leptin is considered to regulate the central
nervous system, there are no reports regarding its association with fatigue in those patients. This
cross-sectional study included 347 patients with cardiovascular risk factors. Fatigue score and
plasma leptin concentration were measured. In addition, abdominal fat accumulation, systemic
inflammation, sleep condition, and functions of hypothalamus-pituitary axis and autonomic
system were estimated. Plasma leptin concentration (natural logarithm transformed) was
significantly and positively (r=0.222, p<0.001) associated with fatigue score, and significantly
(p<0.001) higher in the moderately-fatigued group (2.32±0.75 ng/ml, mean ± SD, n=52) than in
the normally-fatigued group (1.85±1.02 ng/ml, mean ± SD, n=295). Multiple logistic regression
analysis showed that plasma leptin concentration was significantly and independently associated
with a moderately-fatigued condition independent of other factors, including age, gender,
presence of diabetes, hypertension, dyslipidemia, alcohol consumption habit, urinary free cortisol,
serum high-sensitive CRP concentration, visceral and subcutaneous fat area, apnea/hypopnea
index, sleep efficiency, and heart rate variability. Hyperleptinemia may contribute to fatigue
severity in patients with cardiovascular risk factors.
http://www.psyneuen-journal.com/article/S0306-4530(16)30576-5/fulltext
Thought this was interesting. They do talk about chronic fatigue syndrome in the full text, and we've talked about leptin quite a bit on these boards...
-J