And why are they hot - or why should they be not? As far as I can see, we've literature being released. Though like in any field. Most you can bring back to some sound lines of research, others are just replicas of older research (quiet legit in science). Puzzling all the evidence and studies together The big groups (please correct me, fill me in and help me out) 1) CFS is a cardiovasculair problem, even a precursor of real heart failure 2) CFS patients show big leaps in their immunity (lymph nodes being to large from diminished or increased immunity cells) 3) CFS is an auto-immune disorder - the body attacks itself? 4) Mitochondrial problems : problems to the very energy producing motors of the cells, no wonder patients have no energy 5) Sensitive patients -> leaky gut -> penetration of all kinds of litter in the body, poisoning the body and all organs, more and more while more of the intenstinal wall fals apart, leaving no room for "good stuff" or counterbalancing it 6) something is wrong with the gut microbiome 7) virusses or bacterias survived within years of these patients, all the time triggering their immune system, but making them prone to other diseases -> even more bacterias and viruses or harmful substances make their way 8) HPA-as is being stretched too far, the body has been to long in a fight/flight state and is crashing now 9) Certain brain areas are used in a different way than controls do: asking much more energy 10) Patients are in a kind of hibernation mood 11) Roles of sexual hormons (esp in woman, woman tend to go earlier in menopause with CFS, ...) 12) Endocrinological basis I'm trying to get a hint of the literature so far. Does also known something more about the prognosis of CFS persons? Is here any-one being in touch with research groups? I'm only reading here diagonally just for a few weeks and in my opinion, there's tons and tons of information worth looking into, being gathered by all these individual cases.