My wife has been going through a very difficult time now for a few years and we have been unable to find any real answers on her continually declining state. Blood tests have revealed nothing and doctors essentially think there's nothing really going on. For some time she had a hard time taking birth control on a controlled interval and switched to an IUD. This caused perpetual pain and so she had that removed after about 10 months and has moved away to a NuvaRing. It was thought that perhaps the continual pain might be the culprit in sapping her energy and so forth, but sadly there have been no improvements. The situation is becoming debilitating. She is finding herself extremely fatigued day in and day out. Further when she tries to do things such as visiting the store, she is finding herself feeling hot flushes (/ flashes perhaps), dizziness, near fainting with a difficulty breathing that is accompanied by an inability to think clearly. She wakes up tired and stays tired. She finds herself hungry and even has (nonspecific) cravings, but nothing satisfies her. She relates that it feels as though she is not getting nutrients, but she can't figure out what that might be. Never feels better after eating; actually feels more tired after eating no matter what she eats. Feels better when she doesn't eat anything, but this is obviously problematic in and of itself. She has taken piracetam and hordenine and caffeine sometimes (50-200 mg, but not every day; tries to not get used to and addicted to it). She feels like she's getting used to piracetam and hordenine; not feeling real results. She has constant brain fog - can't think straight, feels like she is zoned out most of the time; cannot focus, constant worry about life issues (such as abused step children and other family struggles). Blood tests have come back normal; doctors cannot isolate any problem. Essentially no one is offering real help and she simply is continuing to decline. Any ideas on how to isolate this issue or what to really look for as a primary indication as to what her problem could be?