Hello everyone this is my first post here. I figured I would post it on this thread since it relates. I have felt awful the past 3-4years. Had tons of blood work done been to rheumatologist, endocrinologist, etc. everything typically comes back normal. Rheumatologist just said “you probably have CFS“ and there’s not much you can do about it. I’m thinking a big part of my problem is some type of an iron deficiency. I can’t figure out what in the world is going on with my iron related bloodwork. I am on testosterone replacement therapy and in the past I was referred to do several phlebotomies to lower my hemoglobin. This ended up tanking my ferritin levels. After reading that secondary erythrocythemia induced by hormone replacement therapy does not have the side effects of true erythrocythemia I am not concerned about this as much so I’m more focused on my iron/ferritin. It’s been almost a year since I’ve done a phlebotomy so I could get my iron levels and ferritin increased. The following Labs were taken 4/29/18 Total iron 71 range 50-180 TIBC 382 range 250-425 % saturation 19 range 15-60 Ferritin 29 range 29-345 (This is too low) Transferrin 265 range 188-341 RBC 5.9 range 4.2-5.8 Hemoglobin 17.1 range 13-17 Hematocrit 50.5 range 38-50 RDW 13 range 11-15 MCV 87 range 80-100 Platelets 192 range 140-400 B12 serum 1941 range 200-1100 Folate serum 9.6 range >5.4 Methylmalonic Acid 3.6 range 1.6-29.7 MMA Normalized 1.6 range 0.4-2.5 Homocysteine 4.6 range 0-15 (This seems too low I am doing a methylation Test to check Methionine, cysteine,SamE,etc.. levels) Pregnenolone <5 range 22-237 (This was concerning I recently started supplementing with 15mg transdermal pregnenolone by Life-Flo) Liver,lipids and Jak mutations are normal EPO 14.2 range 2.6-18.5 I recently got a b12 unsat binding test to see if I need to supplement with B12 and the results confuse me. They are very low yet I have high B12 serum and normal MMA. Vitamin B12 Blood Test, Unsaturated Binding Capacity: Result 481 range 725-2045 These are my mutations: MTHFR GT risk allele G (A1298C) MTHFR AG risk allele A (C677T) MTRR GG risk allele G (A66G) MTRR CT risk allele T (C524T) MAOB C risk allele T +/+*(male) COMT AG risk allele A (V158M) COMT CT risk allele T (H62H) GSTP1 GG risk allele G (lle105Val) APOE CC risk allele C (Arg176Cys) Any help is appreciated. Thank you!