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Newly made mitochondrial DNA drives inflammation

Discussion in 'Other Health News and Research' started by Gondwanaland, Aug 3, 2018.

  1. Gondwanaland

    Gondwanaland Senior Member

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    https://www.nature.com/articles/d41586-018-05764-z
     
  2. ljimbo423

    ljimbo423 Senior Member

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    This is a very informative article and I think it ties into the biochemical processes of ME/CFS very well. Thank you for posting it.

    I have been reading about how mitochondria can cause inflammation for a few months now. My feeling is the inflammation from the dysfunctional mitochondria is playing a big part in ME/CFS symptoms.

    Here are a couple more quotes from the paper that jumped out at me-

    I think this first quote is referring to why oxidized mitochondrial DNA triggers the cytokine IL-1B and inflammation.

    This image, as I understand it, shows Reactive oxygen species (ROS) oxidizing mitochondrial DNA and the oxidized mitochondrial DNA triggers inflammasome activation, which causes an increase in Interleukin 1B (IL-1B). Which is a strong innate immune system cytokine.

    Something else I find really interesting in the article is that they use lipopolysacchrides (LPS) to cause the ROS and trigger the inflammasome and IL-1B.

    [​IMG]
     
    Last edited: Aug 3, 2018
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  3. Gondwanaland

    Gondwanaland Senior Member

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    Thank you for extracting the essentials from it, which I do not have the energy to do.
     
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  4. Gemini

    Gemini Senior Member

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    Thanks for pointing out the IL-1B trigger @ljimbo423. Very interesting!

    Montoya's recent paper profiling cytokines 18 hours post exercise cites IL-1B:

    The most discriminatory cytokines post exercise were CD40L, platelet activator inhibitor, interleukin 1-β, interferon-α and CXCL1.

    In conclusion, cytokine profiling following exercise may help differentiate patients with ME/CFS from sedentary controls.

    https://www.ncbi.nlm.nih.gov/pubmed/29426834
     
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  5. ljimbo423

    ljimbo423 Senior Member

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    Nice find! I think exercise in ongoing research will reveal a lot.
     
  6. Wishful

    Wishful Senior Member

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    It certainly helps show how complex the whole immune system is. I was convinced that my disorder involved mitochondria and the immune system long before I realized I had ME, so this new finding fits that nicely. This should give the researchers another perspective on ME.
     
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  7. Gemini

    Gemini Senior Member

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    Agree @ljimbo423 glad you mentioned exercise, prompted me to take another look at Maureen Hanson's recent Iime Conference talk covering her research and "microvesicule" project. This article mentions them:

    "Mitochondria can release microvesicles containing oxidized DNA and protein...the release of mitochondrial nucleic acids to the cytoplasm can act as a signal that triggers a defense response..."

    Thanks for posting this @Gondwanaland! Fascinating link between mitochondrial and inflammatory signaling! In a top scientific journal! Stanford co-authors on the underlying Nature paper, too.

    Summary transcript of Hanson's talk here:
    www.investinme.eu/Iimec13.shtml#report

    Hanson's entire talk is available on DVD that can be ordered:
    www.investinme.eu/Iimec13.shtml#dvd
     
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