Discussion in 'Other Health News and Research' started by Gondwanaland, Aug 3, 2018.
This is a very informative article and I think it ties into the biochemical processes of ME/CFS very well. Thank you for posting it.
I have been reading about how mitochondria can cause inflammation for a few months now. My feeling is the inflammation from the dysfunctional mitochondria is playing a big part in ME/CFS symptoms.
Here are a couple more quotes from the paper that jumped out at me-
I think this first quote is referring to why oxidized mitochondrial DNA triggers the cytokine IL-1B and inflammation.
This image, as I understand it, shows Reactive oxygen species (ROS) oxidizing mitochondrial DNA and the oxidized mitochondrial DNA triggers inflammasome activation, which causes an increase in Interleukin 1B (IL-1B). Which is a strong innate immune system cytokine.
Something else I find really interesting in the article is that they use lipopolysacchrides (LPS) to cause the ROS and trigger the inflammasome and IL-1B.
Thank you for extracting the essentials from it, which I do not have the energy to do.
Thanks for pointing out the IL-1B trigger @ljimbo423. Very interesting!
Montoya's recent paper profiling cytokines 18 hours post exercise cites IL-1B:
The most discriminatory cytokines post exercise were CD40L, platelet activator inhibitor, interleukin 1-β, interferon-α and CXCL1.
In conclusion, cytokine profiling following exercise may help differentiate patients with ME/CFS from sedentary controls.
Nice find! I think exercise in ongoing research will reveal a lot.
It certainly helps show how complex the whole immune system is. I was convinced that my disorder involved mitochondria and the immune system long before I realized I had ME, so this new finding fits that nicely. This should give the researchers another perspective on ME.
Agree @ljimbo423 glad you mentioned exercise, prompted me to take another look at Maureen Hanson's recent Iime Conference talk covering her research and "microvesicule" project. This article mentions them:
"Mitochondria can release microvesicles containing oxidized DNA and protein...the release of mitochondrial nucleic acids to the cytoplasm can act as a signal that triggers a defense response..."
Thanks for posting this @Gondwanaland! Fascinating link between mitochondrial and inflammatory signaling! In a top scientific journal! Stanford co-authors on the underlying Nature paper, too.
Summary transcript of Hanson's talk here:
Hanson's entire talk is available on DVD that can be ordered:
You can also try a Google Site Search
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