The 12th Invest in ME Research Conference June, 2017, Part 2
MEMum presents the second article in a series of three about the recent 12th Invest In ME International Conference (IIMEC12) in London.
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new type of immune cell found which kills viral infected B cells (follicular cytotoxic T cells)

Discussion in 'Other Health News and Research' started by taniaaust1, Nov 13, 2016.

  1. taniaaust1

    taniaaust1 Senior Member

    Sth Australia
    (wow a lot of researchers worked on this study)

    CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles
    Nature Immunology 17, 1187–1196 (2016) doi:10.1038/ni.3543
    Received 19 July 2016
    Accepted 29 July 2016
    Published online 03 August 2016

    During unresolved infections, some viruses escape immunological control and establish a persistant reservoir in certain cell types, such as human immunodeficiency virus (HIV), which persists in follicular helper T cells (TFH cells), and Epstein-Barr virus (EBV), which persists in B cells. Here we identified a specialized group of cytotoxic T cells (TC cells) that expressed the chemokine receptor CXCR5, selectively entered B cell follicles and eradicated infected TFH cells and B cells. The differentiation of these cells, which we have called 'follicular cytotoxic T cells'

    I myself when I had EBV (mono) severely as a teen (extremely sick for 10 weeks to point i had seizures and passouts due to the EBV) have always thought since then I have something wrong or different with my immune system to others. (I got ME 10 years after that mono), so maybe its due to something being wrong with this new type of cell which can kill mono infected cells?. I wish I could have my follicular cytotoxic T cells tested.
  2. anciendaze

    anciendaze Senior Member

    This is encouraging because such highly specific cells can be selected from patient blood using a cell sorter, stimulated, cloned and reintroduced to the same patient in a form of adoptive immunotherapy. Eliminating infected B-cells looks like a promising approach to treating a number of serious diseases that get more respect than ME/CFS. Once preliminary research has been done in treatment for such things as leukemia/lymphoma we can expect to piggyback on that as happened with Rituximab.
    ukxmrv, merylg, Billt and 1 other person like this.
  3. Billt

    Billt Senior Member

    New Orleans
    Thanks for this information. Very exciting, I believe this cold help lots of people
    taniaaust1 likes this.

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