Countrygirl
Senior Member
- Messages
- 5,479
- Location
- UK
in Rheumatol. 2018 Feb 7. doi: 10.1007/s10067-018-4009-2. [Epub ahead of print]
On chronic fatigue syndrome and nosological categories.
Sharif K1,2, Watad A1,2, Bragazzi NL3, Lichtbroun M1,2, Martini M4, Perricone C4,5, Amital H1,2, Shoenfeld Y6,7.
Author information
Abstract
Chronic fatigue syndrome (CFS) is a heterogeneous disease which presents with pronounced disabling fatigue, sleep disturbances, and cognitive impairment that negatively affects patients' functional capability. CFS remains a poorly defined entity and its etiology is still in question. CFS is neither a novel diagnosis nor a new medical condition. From as early as the eighteenth century, a constellation of perplexing symptoms was observed that resembled symptoms of CFS. Commencing with "febricula" and ending with CFS, many names for the disease were proposed including neurocirculatory asthenia, atypical poliomyelitis, Royal Free disease, effort syndrome, Akureyri disease, Tapanui disease, chronic Epstein-Barr virus syndrome, and myalgic encephalitis. To date, it remains unclear whether CFS has an autoimmune component or is a condition that precedes a full-blown autoimmune disease. Research suggests that CFS may overlap with other diseases including postural orthostatic tachycardia syndrome (POTS), autoimmune syndrome induced by adjuvants (ASIA), and Sjögren's syndrome. Additionally, it has been postulated that the earliest manifestations of some autoimmune diseases can present with vague non-specific symptoms similar to CFS. Sometimes only when exposed to a secondary stimulus (e.g., antigen) which could accelerate the natural course of the disease would an individual develop the classic autoimmune disease. Due to the similarity of symptoms, it has been postulated that CFS could simply be an early manifestation of an autoimmune disease. This paper will provide a historical background review of this disease and a discussion of CFS as an entity overlapping with multiple other conditions.
KEYWORDS:
Autoimmune syndrome induced by adjuvants; Chronic fatigue syndrome; Myalgic encephalomyelitis; Postural orthostatic tachycardia syndrome
PMID:
29417255
DOI:
10.1007/s10067-018-4009-2
PubMed Commons home
PubMed Commons
0 comments
How to join PubMed Commons
Supplemental Content
Full text links
Save items
Add to FavoritesView more options
Recent Activity
On chronic fatigue syndrome and nosological categories.
PubMed
See more...
You are here: NCBI > Literature > PubMed
Support Center
On chronic fatigue syndrome and nosological categories.
Sharif K1,2, Watad A1,2, Bragazzi NL3, Lichtbroun M1,2, Martini M4, Perricone C4,5, Amital H1,2, Shoenfeld Y6,7.
Author information
Abstract
Chronic fatigue syndrome (CFS) is a heterogeneous disease which presents with pronounced disabling fatigue, sleep disturbances, and cognitive impairment that negatively affects patients' functional capability. CFS remains a poorly defined entity and its etiology is still in question. CFS is neither a novel diagnosis nor a new medical condition. From as early as the eighteenth century, a constellation of perplexing symptoms was observed that resembled symptoms of CFS. Commencing with "febricula" and ending with CFS, many names for the disease were proposed including neurocirculatory asthenia, atypical poliomyelitis, Royal Free disease, effort syndrome, Akureyri disease, Tapanui disease, chronic Epstein-Barr virus syndrome, and myalgic encephalitis. To date, it remains unclear whether CFS has an autoimmune component or is a condition that precedes a full-blown autoimmune disease. Research suggests that CFS may overlap with other diseases including postural orthostatic tachycardia syndrome (POTS), autoimmune syndrome induced by adjuvants (ASIA), and Sjögren's syndrome. Additionally, it has been postulated that the earliest manifestations of some autoimmune diseases can present with vague non-specific symptoms similar to CFS. Sometimes only when exposed to a secondary stimulus (e.g., antigen) which could accelerate the natural course of the disease would an individual develop the classic autoimmune disease. Due to the similarity of symptoms, it has been postulated that CFS could simply be an early manifestation of an autoimmune disease. This paper will provide a historical background review of this disease and a discussion of CFS as an entity overlapping with multiple other conditions.
KEYWORDS:
Autoimmune syndrome induced by adjuvants; Chronic fatigue syndrome; Myalgic encephalomyelitis; Postural orthostatic tachycardia syndrome
PMID:
29417255
DOI:
10.1007/s10067-018-4009-2
- Share on Facebook
- Share on Twitter
- Share on Google+
PubMed Commons home
PubMed Commons
0 comments
How to join PubMed Commons
Supplemental Content
Full text links
Save items
Add to FavoritesView more options
Recent Activity
On chronic fatigue syndrome and nosological categories.
PubMed
See more...
You are here: NCBI > Literature > PubMed
Support Center