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neurometabolic abnormalities in CFS , GAD and MDD.

Discussion in 'Latest ME/CFS Research' started by leelaplay, Jul 28, 2010.

  1. leelaplay

    leelaplay member

    Tate Mitchell to CO-CURE today

    (my bolds and spacing)

    NMR Biomed. 2010 Jul;23(6):643-50.

    Increased ventricular lactate in chronic fatigue syndrome measured by
    (1)H MRS imaging at 3.0 T. II: comparison with major depressive

    Murrough JW, Mao X, Collins KA, Kelly C, Andrade G, Nestadt P, Levine
    SM, Mathew SJ, Shungu DC.

    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.


    Chronic fatigue syndrome (CFS), a complex illness characterized by
    fatigue, impaired concentration, and musculoskeletal pain, is often
    misdiagnosed as a psychiatric illness
    due to the overlap of its
    symptoms with mood and anxiety disorders.

    Using proton magnetic resonance spectroscopic imaging ((1)H MRSI),
    we previously measured levels of the major brain metabolites in CFS,
    in generalized anxiety disorder (GAD), and in healthy control subjects,
    and found significantly higher levels of ventricular cerebrospinal fluid (CSF)
    lactate in CFS compared to the other two groups.

    In the present study,
    we sought to assess the specificity of this observation for CFS by
    comparing ventricular lactate levels in a new cohort of 17 CFS
    subjects with those in 19 healthy volunteers and in 21 subjects with
    major depressive disorder (MDD), which, like GAD, is a
    neuropsychiatric disorder that has significant symptom overlap with

    >Ventricular CSF lactate was significantly elevated in CFS
    compared to healthy volunteers, replicating the major result of our
    previous study.

    >Ventricular lactate measures in MDD did not differ
    from those in either CFS or healthy volunteers.

    >We found a significant
    correlation between ventricular CSF lactate and severity of mental
    fatigue that was specific to the CFS group.

    >In an exploratory
    analysis, we did not find evidence for altered levels of the amino
    acid neurotransmitters, gamma-aminobutyric acid (GABA) and glutamate +
    glutamine ('Glx'), in CFS compared to MDD or healthy controls.

    (1)H MRS studies with larger sample sizes and well-characterized
    populations will be necessary to further clarify the sensitivity and
    specificity of neurometabolic abnormalities in CFS and MDD. Copyright
    (c) 2010 John Wiley & Sons, Ltd.

    PMID: 20661876 [PubMed - in process]

    So - last study CSF was higher in CFS than healthy controls or people with GAD (general anxiety disorder)

    This study - I'm not sure I understand the 2ndary results
    CSF higher in CFS than in healthy = validates previous study results

    BUT - MDD is not differentiated from CFS or healthy. I'm not sure I get that. Does it mean for MDD the results range is much wider - going from the same as healthy up to the same as CFS?

    Whatever the case - this looks quite promising. And like that it's a Psych Dept proving biomedically that CFS is different from mental illnesses
  2. Dolphin

    Dolphin Senior Member

    That's what it sounds like to me - a large-ish SD.

    A bigger study might have reached significance.

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