Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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Need help with 23andme results

Discussion in 'Genetic Testing and SNPs' started by longroad_pvg, Dec 11, 2013.

  1. longroad_pvg


    Hey everyone, I am really excited to be here. I have significant problems with fatigue which are even more noticeable after exercise. People often seem to recommend working out to have more energy but I feel like I immediately need a nap even from less than rigorous exercise. I have both cognitive and physical fatigue as well as low mood. I have been reading the past few weeks on this website to help me better understand what is going on as well as on Heartfixer and the howirecovered. I think I have a bit of an understanding as well from reading some of the information posted to other 23andme threads but any suggestions and comments are always welcome. I have attached my results below but here is a summary:



    VDR Bsm
    VDR Taq
    MTHFR C677T
    MTR A2756G
    MTRR A66G
    MTRR H595Y
    MTRR K350A
    MTRR A664A

    Obviously, I have serious issues with the methylation cycle with 5/6 MTRR being heterozygous and MTR and an MTHFR heterozygous. My COMT and MAO-A are normal which leads me to believe that I will have problems with under methylation. Looking at various protocols, I determined to try the protocol for methylation by Freddd.

    1) Mb12 (Enzymatic Therapy) "Start Here"
    2) Methylfolate (Solgar)
    3) AdB12 (Country Life Active)
    4) L-carnitine Fumerate
    5) Potassium (As needed, Have some already on hand)

    There are many other threads that discuss it in more detail but the general idea would be to follow the advice of the protocol and go in order adding the various substances as Freddd recommends.

    Since I have both heterozygous VDR, I planned on beginning Vitamin D supplementation at around 2000 IU. In the past, I have felt some benefit from these supplements which I noticed mainly after stopping them and they definitely seem to take time to start working.

    Also, what are the recommendations for ACAT? Bile salts? Any suggestions for brands and quantity.


    CYP1B1 L432V

    CYP1A2 164A>C
    CYP1B1 R48G
    CYP2D6 All of them
    GSTP1 I105V
    SOD2 A16V
    NAT2 I114T
    NAT2 R197Q
    NAT2 K268R

    I am a little confused about these but SOD2 seems to possibly cause mitochondrial problems so I need support for that. Also the CYP1B1 problems, I believe that I should eat more cruciferous vegetables to help with possible estrogen issues. I also understand that the NATs detox smoke so I should stay away from that which is no problem since I do not smoke.

    I also wanted to say that I have been working on my diet. I use Cronometer to track both calories and essential nutrients that I am getting. I aim for mainly Primal foods (Paleo plus milk products occasionally). I generally hit the recommended values for basically everything. Should I supplement other sources as well like Vitamin C or A? I know Zinc is very important so maybe that? Any thoughts?

    Those are my general ideas on my various problems. Any advice would be greatly appreciated as well as any additional interpretations that I might have missed or other suggestions.

    Thank you,

    Attached Files:

  2. Biohacker


    For CYP1B1 I suggest DIM-plus, which seems to be much more effective than raw vegetables, extracts, or I3C

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