vision blue
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I just got my results for neuro biogenic amines. Comments are welcome and if anyone else has taken the test or equivalent, i would be interested in comparing. i've also done amino acid (AA) test 3 times, but will talk about that some other time.
Here are some things i've noticed and some comments. NOte that for highs and lows, I typically do not look at having to exceed the 95th or 2.5th percentile, but rather highs and lows with respect to other analytes in the test. So for this test, although only one thing officially out of range, there is nontheless some patterns.
My dopamine is relatively high, as is 3-MT, but DOPAC is relatviely low
My tyrosine is low , but tyramine is high (note from AA testing, my phenalanine is fine)
Not sure if histamine is trending towards high.
On this test glutamate seems fine, but on AA tests my glutimate is always high.
My taurine is high, and GABA is up there- all sensible and will comment below if i don't run out of time.
No elevations in seretonin, or its metabolite PEA, or in epinephrine (adreniline), or nor epineprhine (note this is first morning urine only which may make a difference; also, i had a test by another lab suggesting those were high, but i don't trust the lab)
Metenphrines normal (agrees with a conventional doctor ordered test from ARUP labs)
Some comments:
Generally, i have symptoms of sympathetic excess that's like the sympathetic nervous system never quits, especially when i get an excaberation, and moreover have had side effects from tyramine-containing foods, so i was not surprised to see dopamine and tyramine (and histamine?) on the high side.
On dopamine, DOPAC and 3-MT
Dopamine is converted to DOPAC first using MAO while dopamine is converted to 3-MT first using COMT.
Since my dopamine is high and so is 3-MT, I conclude I have no trouble with the COMT pathway. dopamine easily was broken down into 3-MT, hence it too was high. This makes perfect sense, since genetically I am an over methylator and had no troublesome COMT mutations. On the other hand, since my dopamine is high but DOPAC is low, I conclude that MAO did not do its job and dopamine was not broken down by MAO into DOPAC, so dopac did not rise. This too makes alot of sense. Years ago, when i realized i was having big problem with tyramine foods, i had wondered if i was in fact naturally deficient in MAO-A. i'm not sure its exaclty the right interpretation given these new results, but its involved. Genetically, i'm heterozygous for the MAO-A gene so should have an intermediate level of the enzyme - that mutation alone is not sufficient to explain why its not really doing its job.
So one issue, is i likely have trouble having enuf MAO-A. whether ists just that its overwhelmed by too much dopamine (if so, reason unknown), or there objectively isn't enough, or somehow being an over methylator negatively affects the mao pathway, don't know.
note also that I know much of dopamine is elsewhere, only 20 percent or so brain, and i certainly have GI symptoms - BUT since i also have brain/neuro symptoms for sure, to ignore this and say its just picking up gut or elsewhere in body seems incorrect.
ok, so now i'm spent. I will have to finish typing my comments on the other patterns of results at a later time.
Here are some things i've noticed and some comments. NOte that for highs and lows, I typically do not look at having to exceed the 95th or 2.5th percentile, but rather highs and lows with respect to other analytes in the test. So for this test, although only one thing officially out of range, there is nontheless some patterns.
My dopamine is relatively high, as is 3-MT, but DOPAC is relatviely low
My tyrosine is low , but tyramine is high (note from AA testing, my phenalanine is fine)
Not sure if histamine is trending towards high.
On this test glutamate seems fine, but on AA tests my glutimate is always high.
My taurine is high, and GABA is up there- all sensible and will comment below if i don't run out of time.
No elevations in seretonin, or its metabolite PEA, or in epinephrine (adreniline), or nor epineprhine (note this is first morning urine only which may make a difference; also, i had a test by another lab suggesting those were high, but i don't trust the lab)
Metenphrines normal (agrees with a conventional doctor ordered test from ARUP labs)
Some comments:
Generally, i have symptoms of sympathetic excess that's like the sympathetic nervous system never quits, especially when i get an excaberation, and moreover have had side effects from tyramine-containing foods, so i was not surprised to see dopamine and tyramine (and histamine?) on the high side.
On dopamine, DOPAC and 3-MT
Dopamine is converted to DOPAC first using MAO while dopamine is converted to 3-MT first using COMT.
Since my dopamine is high and so is 3-MT, I conclude I have no trouble with the COMT pathway. dopamine easily was broken down into 3-MT, hence it too was high. This makes perfect sense, since genetically I am an over methylator and had no troublesome COMT mutations. On the other hand, since my dopamine is high but DOPAC is low, I conclude that MAO did not do its job and dopamine was not broken down by MAO into DOPAC, so dopac did not rise. This too makes alot of sense. Years ago, when i realized i was having big problem with tyramine foods, i had wondered if i was in fact naturally deficient in MAO-A. i'm not sure its exaclty the right interpretation given these new results, but its involved. Genetically, i'm heterozygous for the MAO-A gene so should have an intermediate level of the enzyme - that mutation alone is not sufficient to explain why its not really doing its job.
So one issue, is i likely have trouble having enuf MAO-A. whether ists just that its overwhelmed by too much dopamine (if so, reason unknown), or there objectively isn't enough, or somehow being an over methylator negatively affects the mao pathway, don't know.
note also that I know much of dopamine is elsewhere, only 20 percent or so brain, and i certainly have GI symptoms - BUT since i also have brain/neuro symptoms for sure, to ignore this and say its just picking up gut or elsewhere in body seems incorrect.
ok, so now i'm spent. I will have to finish typing my comments on the other patterns of results at a later time.